Formulation and Evaluation of Floating Microspheres of Ciprofloxacin by Solvent Evaporation Method Using Different Polymers

Abstract

Objective: The main intention of this research was to formulate and evaluate floating microspheres of ciprofloxacin using different polymers to prolong gastric residence time.
 Methods: The microspheres were formulated by the solvent evaporation method using different ratios of polymers like carbopol 940, ethylcellulose, and Hydroxy Propyl Methyl Cellulose K4M. Further, the floating microspheres were evaluated for micromeritic properties like bulk density, tapped density, angle of repose, etc., percentage yield, particle size, entrapment efficiency, floating capacity, in vitro drug release study, release kinetics, drug content, swelling index, and Fourier Transform Infrared Spectroscopy (FTIR) (Compatibility studies).
 Results: The ciprofloxacin microspheres showed the good flowing property. The particle size ranged from 258.1±2.21 µm to 278±2.86 µm and entrapment efficiency ranged from 63.17±0.43% to 89.90±1.32%. The IR spectrum revealed that there was no interaction between the drug and polymer. F7 formulation was found to be the best formulation. Drug release was found to be 90.70±0.89% i.e. in a controlled manner at the end of 10 h.
 Conclusion: The floating microspheres were prepared successfully and the results clearly stated that prepared ciprofloxacin microspheres may be safe and effective controlled drug delivery over an extended period which can increase bioavailability, patient compliance, and decrease dosing frequency.

Influence of pH on the release of a once daily formulation of ciprofloxacin tablets prepared with different polymers

“…Improved release of ciprofloxacin hydrochloride in acidic pH has been reported and hence a formulation of ciprofloxacin that could swell so that is retained in a fed stomach was designed [17]. Also, it was reported that ciprofloxacin showed reduced bioavailability from the colon (pH 7.4) in an in vitro study of slow-release release ciprofloxacin in intestinal model [18].…”

Pengaruh Laju Alir pada Proses Spray Drying terhadap Karakteristik Fisiko Kimia Mikrosfer Glibenklamid menggunakan Polimer Kitosan dan Penyambung Silang Natrium Tripolifosfat

“…Perolehan kembali diperoleh dari rasio antara bobot mikrosfer yang dihasilkan dengan bobot total bahan yang digunakan dan dihitung dalam persen [11]. Pengujian ini dilakukan untuk menganalisis perbedaan laju alir pada proses spray drying terhadap perolehan hasil mikrosfer.…”

Elaboration of bread with the incorporation of coconut pulp flour and sacha inchi (Plukenetia volubilis L.) nibs

“…La harina de pulpa de coco es aquella hecha del subproducto de la obtención de leche de coco, esta harina no posee gluten, pero si alto contenido de fibra que puede considerarse potencialmente como alimento funcional Erminawati et al (2017). Esta fibra se relaciona con varios efectos fisiológicos y metabólicos; por ejemplo, en el tracto digestivo la fibra dietética ejerce un efecto amortiguador que vincula el exceso de ácido en el estómago aumentando el volumen fecal y estimulando la evacuación intestinal, además, proporciona un ambiente favorable para el crecimiento de la flora intestinal beneficiosa (Arumugam et al, 2015); por lo indicado actualmente las personas son más conscientes del consumo de alimentos saludables. La harina de coco puede ser utilizada como material para sustituir la harina de trigo en la elaboración de pan, fideos y galletas Dat y Phuong (2017).…”