Formulation and evaluation of floating tablet of H₂-receptor antagonist

Abstract

Ranitidine HCl matrix floating tablets were formulated to release 90% of drug in stomach within 12 h. Hence, release of the drug could be sustained within narrow absorption site. Moreover, the dosage form was found to be floating within a fraction of second independent of the pH of media ensuring a robust formulation.

Formulation and in Vitro Evaluation of Amlodipine Gastroretentive Floating Tablets Using a Combination of Hydrophilic and Hydrophobic Polymers

“…From these results, it can be detected that those batches with a low concentration of polymer showed less thickness of the tablets obtained due to lower concentrations of polymer. Moreover, a higher concentration of polymers produces more thickness for tablets and less dense [30].…”

Preparation and evaluation of floating tablets of pregabalin

“…Gastro-retentive systems (floating tablets, pellets or beads) were successfully developed and evaluated for several category of drugs like antihistamines (cetrizeine, famotidine, ranitidine), NSAIDS (ketorolac, celecoxib), antibiotics (metronidazole, ofloxacin, amoxicillin), antidiabetics (metformin, repaglinide) and many more [8][9][10][11][12][13][14][15][16][17] .…”

A Review on Novel Approaches Incorporated in the Formulation of Gastro Retentive Drug Delivery System

“…This prolonged gastric retention enhances bioavailability, decreases drug wastage, and improves solubility of drugs that are less soluble at high pH environment. [18,19] Ideal characteristics of drugs for GRDDS Drug molecules that have poor colonic absorption but have improved absorption at upper region of gastro intestinal tract are desirable candidates for the formulation of GRDDS. Identification of physical, chemical and biological properties of the drug should be determined before development of GRDDS.…”