Formulation and Evaluation of Floating Matrix Tablets of Pioglitazone Hydrochloride delivery

Chithaluru, Kalyani; Thallepalli, Sunanda; Kanaparthy, Vijaya Kumar

doi:10.4103/2045-080x.112814

Arch Pharma Pract

2012

DOI: 10.4103/2045-080x.112814

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Formulation and Evaluation of Floating Matrix Tablets of Pioglitazone Hydrochloride delivery

Kalyani Chithaluru¹,

Sunanda Thallepalli²,

Vijaya Kumar Kanaparthy³

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Formulation and Evaluation of Floating Drug Delivery System of Repaglinide

Begum¹,

rani²

2023

Asian J Pharm Clin Res

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Objective: The present study’s is to develop floating drug delivery system of repaglinide. Methods: Moringa gum, Repaglinide, HPMC K100M, Sodium alginate, Calcium Carbonate, Sodium Citrate. The obtained formulation was evaluated for drug content, pH, in vitro gelling capacity, in vitro buoyancy studies, and in vitro dissolution studies. Results and Discussion: All the total F1-F12 formulations showed pH ranging from 5.1 to 7.9, floating lag time of F1-F12 ranging from 5 s to 12 s with total floating time greater than 12 h, viscosity of F1-F12 ranging from 619 to 3856 cp, drug content of F1-F12 ranging from 31.2% to 93.1%, and percent drug release of F1-F12 ranging from 78.9% to 93.9%. Dissolution studies showed that F12 formulation-containing drug (30 mg) and polymer (4000 mg) showed 93.9% drug release in 12 h which is said to be optimized. Thus, the best formulation (F12) was subjected for a 3-month period of stability studies found to be stable and reported no significant change. Conclusion: The study’s goal is to develop and evaluate floating in situ gel forming solution of repaglinide with moringa gum as rate retardant polymer.

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Formulation and Evaluation of Floating Drug Delivery System of Repaglinide

Begum¹,

rani²

2023

Asian J Pharm Clin Res

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Formulation and Evaluation of Floating Matrix Tablets of Pioglitazone Hydrochloride delivery

Cited by 1 publication

References 0 publications

Formulation and Evaluation of Floating Drug Delivery System of Repaglinide

Formulation and Evaluation of Floating Drug Delivery System of Repaglinide

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