Formulation and Evaluation of Herbal Antibacterial Gel Containing Ethanolic Extract of Mikania Micrantha Kunth Leaves

Harahap, Nina Irmayanti; Nainggolan, Marline; Harahap, Urip

doi:10.22159/ajpcr.2018.v11i3.22211

Cited by 12 publications

(11 citation statements)

References 6 publications

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“…A zone of inhibition measuring more than 8 mm signifies that bacteria are susceptible to sample [ 30 ]. MMLE contains tannins, flavonoids, and polyphenols, exhibiting potential antibacterial activities [ 26 , 31 , 32 ]. Polyphenols have toxicity towards microbial enzymes, while structural features of flavonoids may help gain entry into the bacterial cell, which eventually leads to multiple component inactivation [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

The Potency of Wound Healing of Nanogel-containing Mikania micrantha Leaves Extract in Hyperglycemic Rats

Sumantri

Ismayadi

Mustanti

2021

PNT

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Introduction: Mikania micrantha has been used traditionally for wound dressings and promoted the healing of sores. This is due to the content of alkaloids and terpenoids/steroids compounds. Hyperglycemic is a good medium for bacterial growth and inhibits the wound healing process. Purpose: This study aimed to determine the wound healing of nanogels containing MMLE in hyperglycemic rats, as a model for diabetic wounds. Methods: Mikania micrantha leaves were extracted with the maceration method using ethanol 96% in 5 days. Carbopol 940 was used as the gelling agent. The parameters observed during the physical testing of nanogels were organoleptic, homogeneity, pH, and size of the particle. Antibacterial activity was tested on Staphylococcus aureus, Staphylococcus epidermis, Escherichia coli, and wound healing activity in hyperglycemic rats for 14 days observation. Diabetic wound healing was treated with 4 groups (P1, P2, K1, K2). Data were analyzed using SPSS. Results: Nanogel showed homogeneity, dark green color, transparency, pH 6.1± 0.1, and particle size range in 255-456 nm. Inhibition zone of antibacterial testing i.e. Staphylococcus aureus, Staphylococcus epidermis, and Escherichia coli was 10.57 ± 0.26 mm; 9.73 ± 0.21 mm; 8.4 ± 0.1 mm. The percentage of diabetic wound healing was in the range of 92.79±3.81% to 94.08 ± 2.33% for 14 days of observation. Conclusion: MMLE nanogels have the potential as a treatment for diabetic wound healing.

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Section: Discussionmentioning

confidence: 99%

The Potency of Wound Healing of Nanogel-containing Mikania micrantha Leaves Extract in Hyperglycemic Rats

Sumantri

Ismayadi

Mustanti

2021

PNT

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“…The present research work focused on the development of novel herbal gel formulation based on phytosomal technology because of easy acceptability of herbal formulation, enhanced bioavailability, high efficacy, and less adverse effects. The herbal gel can also be used to treat skin diseases, especially Acne vulgaris 15 . World Health Organization (WHO), as well as our country, has been promoting use of traditional medicine because they are less expensive, easily available and comprehensive, especially in developing countries 16 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2019

IJPSR

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Planterosomal gel exhibit better pharmacokinetic and pharmacodynamic profile than the conventional herbal extracts. The objective of the present research work was to develop, characterize and evaluate the in-vitro antifungal activity of planterosomal gel in comparison to pure plant extract. Planterosomal gel of Ganoderma lucidum was prepared by incorporating gelling agent in planterosomal suspension. Planterosomal gel of G. lucidum was subjected to different evaluation parameters like pH, spreadability, in-vitro release study, exvivo permeation study, and in-vitro antifungal activity. Results of in-vitro release studies and ex-vivo skin permeation studies showed that the planterosomal gel releases the active ingredients in a controlled manner and showed higher skin permeability in comparison to G. lucidum gel. The optimized planterosomal gel showed moderate antifungal activity when compared with a standard antifungal agent. So, it was concluded that the planterosomal gel is an advanced form of herbal formulation which enhances the retention time and skin permeability when applied topically.

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“…Acne vulgaris is one of the most frequent skin (1) illnesses in teenagers, with a frequency of 80-90 percent, and in cases of acute dis guration, it can have serious effects for young people's personality development, which is linked to a high psychological distress (2) . Many patients do not cure with present anti-acne therapy due to high costs, side effects that cause non-compliance, or a lack of therapeutic bene ts from current antibiotics, all while clinically bene cial drugs face substantial hurdles like liver functioning problems, kidney damage, ear poisoning and many more (2) . As a result, in the area of antimicrobial therapy, emphasis has been placed on safer, novel, and harmless alternative antimicrobial ingredients.…”

Section: Introductionmentioning

confidence: 99%

“…The e ciency of topical treatment is mostly determined by the pace and extent of drug release. A topical drug delivery system designed to deliver a range of medications to the body through diffusion throughout the skin layers (2) .…”

Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of antibacterial gel containing ethanol extract of thorns of Bombax ceiba

chauahn¹,

Monika²

2022

Preprint

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Purpose Formulation and evaluation of the herbal gel preparation from the thorn’s extract of Bombax ceiba to check its antibacterial activity against the bacteria Staphylococcus aureus and Propionibacterium acnes Methods Agar well diffusion method were employed for the purpose. Results Gel formulation of different concentration of extract were formulated that is 2%, 4%, 6% and 8% respectively and antibacterial activity of the gels were measured against the bacteria Staphylococcus aureus and Propionibacterium acnes. In this clindamycin gel was used as the standard for comparative analysis. From evaluation results it was concluded that formulation of 8% showed better antibacterial activity as compared to other formulated preparations. In addition to this, evaluation of gel formulations was performed considering various parameters which were pH, appearance, viscosity, spreadibility and homogeneity and the result were calculated. Conclusion The ethanol thorn’ extract of Bombax ceiba possess good antibacterial property against the Staphylococcus aureus and Propionibacterium acnes. It also contains various phytoconstituents which may be helpful in various health related problems.

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Formulation and Evaluation of Herbal Antibacterial Gel Containing Ethanolic Extract of Mikania Micrantha Kunth Leaves

Cited by 12 publications

References 6 publications

The Potency of Wound Healing of Nanogel-containing Mikania micrantha Leaves Extract in Hyperglycemic Rats

The Potency of Wound Healing of Nanogel-containing Mikania micrantha Leaves Extract in Hyperglycemic Rats

Untitled

Formulation and evaluation of antibacterial gel containing ethanol extract of thorns of Bombax ceiba

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