Formulation and Evaluation of Mucoadhesive Tablets Containing Eugenol for the Treatment of Periodontal Diseases

Abstract

Eugenol is the principle chemical constituent of clove oil and has been used to cure dental problems for ages. Eugenol is an integral part of the dentist's kit due to its analgesic, local anesthetic, anti-inflammatory, and antibacterial effects. It is used in the form of a paste or mixture as dental cement, filler, and restorative material. This study reports the development and evaluation of controlled-release mucoadhesive tablets for gingival application, containing eugenol, which are prepared by taking carbopol 934 P and Hydroxypropyl methylcellulose (HPMC) K4M in the ratio of 1:2, 1:1, and 2:1. Incorporation of eugenol (10 mg) in a mucoadhesive formulation provides controlled release for a period of 8 hours, which is advantageous over conventional use. In vitro mucoadhesion measured as detachment force in grams and the formulations show good correlation in vivo. The release study indicates that increase in carbopol increases the release rate of eugenol from the formulation whereas HPMC retards it. Increased in vitro bioadhesion is related to HPMC content of the formulation. The release kinetics of eugenol in vitro correlates with the in vivo results. This indicates the increased potential of eugenol as antibacterial, local analgesic, and anaesthetic treatment.

Volatile constituents of essential oils isolated from leaf and inflorescences of Piper longum Linn.

“…An antiseptic ointment of eugenol with hydrous wool fat has been used for eczema. Eugenol is administered, in the same manner as oil of cloves in phthisis, as a carminative and antiseptic (Jadhav et al 2004). It is a key ingredient in Indonesian kretek (clove) cigarettes.…”

Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposure

“…Conflicting results have been reported by Ahmad et al 19 , who noted that FR strains had higher sensitivity to eugenol than the standard or clinical strains did. In addition to its use as an antiseptic agent, eugenol is applied topically to dental cavities, used as a component of dental protectives, and combined with zinc oxide to form zinc oxide eugenol, which has restorative and prosthodontic applications in dentistry 20 . The fungistatic and fungicidal activities of thymol were similar in the three groups.…”

Bioactive Compounds from Medicinal Plants and Their Importance in Drug Discovery in Pakistan

“…On the other hand simple phenols (e.g. euginol, hydroquinone, catechol, phloroglucinol and p-anisaldehyde) [124], the C6-C3 phenyl propanoids and their derivatives (caffeic acid, cinnamic acid, ferulic acid myristicin and synapyl alcohol), the C6-C1 benzoic acids (gallic acid, vannilic acid and protocatechic acid), coumarins (warfarin, scopoletin and dicoumarol), hydrozable tannis (gallotannins and ellagitannins) and lignans and related compounds all are included in non-flavonoid phenolic compounds.…”