Formulation and evaluation of orodispersible tablet of montelukast sodium

Sahu, Siddharth Kumar; AJAZUDDIN, .; Banjare, Tripti; Gupta, Swapnil; Bhandarkar, Akansha; Sahu, Hemlata; Diwedi, Shradha Devi; Sahu, Pankaj; Agrawal, Palak; Yadav, Pooja; Bhatt, Aditi; Sahu, Kailash C.; Dewangan, Deeksha; Thapa, Hemlata; Deepika,; Sahu, Gyanesh Kumar; Sharma, Mukesh; Tripathi, D. K.; Alexander, Amit

doi:10.5958/0974-360x.2018.00209.3

Cited by 5 publications

(1 citation statement)

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“…Percentage (%) cumulative drug release studies have been performed for the following batches i. It can be seen that % CDR of formulation with modified k-Carrageenan was much higher than formulation with traditional disintegrant and it was comparable with % CDR of formulation with SSG (Superdisintegrant) 20,21 .…”

Section: Trace Analysis Of Linkermentioning

confidence: 99%

Modification of natural hydrocolloid as disintegrant in aceclofenac tablet formulation

Gupta

Manigauha

2021

J. Drug Delivery Ther.

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The purpose of present exploration was to modify kappa (k)-Carrageenan, by crosslinking, and assessed it as a tablet disintegrant to strengthen the solubility of the drug (aceclofenac) in tablet formulation. Modified k-Carrageenan was synthesized by reacting it with epichlorhydrin at heterogenous conditions. The swelling action of the product was investigated in order to optimize reaction circumstances for chemical cross-linking. Best modified k-Carrageenan procured by optimizing the reaction conditions and it was characterized for swelling index, particle size distribution, solubility, viscosity, gel strength and Fourier transform infrared spectroscopy (FTIR). Influence of modified k-Carrageenan on dissolution profile of therapeutic was also investigated along with other evaluation parameters. Modified k-Carrageenan exhibiting significant swelling index which is comparable to that of superdisintegrants. On comparative investigation as a tablet disintegrant by preparing anhydrous dicalcium phosphate tablet, modified k-Carrageenan showed disintegration time less than 20 seconds. Dissolution of aceclofenac (Class II) tablet formulaion utilizing modified k-Carrageenan was comparable with commercially available superdisintegrants. Faster dissolution of the accommodated drug was achieved with modified k-Carrageenan which was comparable with dissolution of the tablet formulation containing other superdisintegrants. The competent concentration of k-Carrageenan was found to be 5-15% as tablet disintegrant. Modified k-Carrageenan might be encouraging tablet disintegrant in fast dissolving formulations and can be worn in direct compression method. Keywords: k-Carageenan. Epichlorhydrin. Aceclofenac. Crosslinking. Superdisintegrant

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Section: Trace Analysis Of Linkermentioning

confidence: 99%

Modification of natural hydrocolloid as disintegrant in aceclofenac tablet formulation

Gupta

Manigauha

2021

J. Drug Delivery Ther.

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Optimization and Evaluation of Orodispersible Solid Dispersion Tablet of Ketotifen Fumarate

Salman

2021

RJPT

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The present study was aimed to integrate the developed and optimized ketotifen fumarate dispersion into Orodispersible tablets formulations, to enhance the dissolution rate and bioavailability aspects of the drug. Ketotifen fumarate solid dispersion was prepared using different concentrations of poloxamer 407via solvent evaporation and fusion method. Solubility study, x-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and other investigations were done. Ten formulations of the optimum dispersed ketotifen fumarate Orodispersible tablets were prepared with various superdisintegrants, the results of in vitro - in vivo tests revealed that, the dispersion of the drug in the polymer considerably enhanced the solubility, the batch (Fsd 3) prepared by fusion method showed increased the solubility as ~2-fold compared with a pure drug. FTIR spectra, SEM and XRD data, showed amorphrization of ketotifen fumarate, which explains the better dissolution rate of the drug from its solid dispersions. Formulation F1 containing 15%w/w of crospovidone was showed in vitro- in vivo disintegration time (17 sec., 15 sec. respectively) and percent of drug dissolved in 2 min. was 90.04%, proved to be the optimum formulation, which is required for obtaining rapidly disintegrating tablets. The solubility of the drug had increased, and the resultant orodispersible tablets can be considered as a promising dosage form to achieve better patient compliance.

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Formulation and Evaluation of Orodispersible Tablets Containing Taste Masked Mirabegron Resinate

Malode¹,

Wagh²

2021

RJPT

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The objective of present work was to develop taste masked orodispersible tablets of mirabegron. Mirabegron is beta 3 adrenoceptor agonist used to treat overactive bladder. Overactive bladder (OAB) is defined as a symptom syndrome showing feeling of urgency to urinate, typically accompanied by frequent daytime and nocturnal urination, in the absence of proven infection or other obvious pathology. Over active bladders are generally common in geriatrics. Moreover, this drug has a very strong bitter taste. Frequent dosing requires frequent water intake, which further aggregates the condition of over active bladder and bitter taste of drug affects patient compliance. Hence a need arises to mask the bitter taste for development of an ODT which does not require consuming water with every dosage. In this work, the bitter taste of mirabegron was masked by forming a complex with an ion exchange resin tulsion 344. The drug resin complexation process was optimized for resin activation, drug: resin ratio, soaking time and stirring time. In –vitro release studies revealed complete drug elution from the complex within 10 minutes in pH 1.2 buffer. The taste-masked complex was then formulated into palatable orodispersible tablets using a direct compression approach by use of superdisintegrants to achieve a rapid disintegration. The tablets were evaluated for weight variation, hardness, friability, drug content, wetting time, In- vivo disintegration time and in-vitro dissolution time.

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Formulation and evaluation of orodispersible tablet of montelukast sodium

Cited by 5 publications

References 0 publications

Modification of natural hydrocolloid as disintegrant in aceclofenac tablet formulation

Modification of natural hydrocolloid as disintegrant in aceclofenac tablet formulation

Optimization and Evaluation of Orodispersible Solid Dispersion Tablet of Ketotifen Fumarate

Formulation and Evaluation of Orodispersible Tablets Containing Taste Masked Mirabegron Resinate

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