Formulation and evaluation of polyethylene glycol/Xanthan gum-co-poly (Acrylic acid) interpenetrating network for controlled release of venlafaxine

Pervaiz, Fahad; Tanveer, Wajeeha; Shoukat, Hina; Rehman, Sadia

doi:10.1007/s00289-022-04098-1

Cited by 9 publications

(3 citation statements)

References 53 publications

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“…The structural aspects of PEG-based hydrogels, including swelling properties, tensile strength, and molecular transport properties, have been extensively studied. This investigation found that modest molecular weight medications could be converted into PEG-based controlled release systems containing big biomacromolecules such as nucleic acids, peptides, and proteins [65][66][67][68][69][70]. The stability and capability of releasing the correct dosage of the active substance of PEG hydrogels are necessary for obtaining a drug's desired therapeutic efficacy [71][72][73].…”

Section: Resultsmentioning

confidence: 99%

Meta-Analysis of Polyethylene Glycol and Cellulose-based Polymers in Vaccine and Drug Delivery: A Comprehensive Review

Aldaais¹

2023

Preprint

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Due to their distinct physical, chemical, and biological characteristics, biopolymers, in particular Poly Ethylene Glycol (PEG) and Cellulose, are frequently used in biomedical medicine as drug or vaccine delivery systems. In this study, we have done a systematic review and a meta-analysis to compare current developments in many PEG and cellulose-based hydrogels, including double network hydrogels, injectable hydrogels, sliding hydrogels, conductive hydrogels, responsive hydrogels, and nanocomposite hydrogels. The pharmacokinetic properties, including physicochemical properties, biocompatibility, biodegradability, temperature, and pH, have been studied as these critical factors are to be considered for deciding the suitability of the drug for delivery. Moreover, the study has evaluated the controlled-release parameters such as half-life, circulation time, maximum release percentage of loaded drug released, burst release, maximum release, and drug-release kinetics. Finally, the efficacy and immune response of hydrogel was studied for future choice, including the cellulose hydrogel system in COVID-related long-term vaccine delivery. The finding revealed that cellulose-based hydrogel is effective for vaccine delivery.

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Section: Resultsmentioning

confidence: 99%

Meta-Analysis of Polyethylene Glycol and Cellulose-based Polymers in Vaccine and Drug Delivery: A Comprehensive Review

Aldaais¹

2023

Preprint

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“…Many fundamental studies have revealed the structural properties of PEG-based hydrogels, such as swelling properties, mechanical properties, and molecular transport properties. Based on these studies, PEG-based controlled release systems containing large biomacromolecules such as nucleic acids, peptides and proteins have been prepared from small molecular weight drugs [20][21][22][23][24][25]. Two important considerations in the design of PEG hydrogels are stability and bioavailability.…”

Section: Polyethylene Glycol (Peg)mentioning

confidence: 99%

The Usage of PEG in Drug Delivery Systems- A Mini Review

Yenilmez¹

2022

PSPRJ

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Designing polymeric delivery systems for drugs and genes to implement individual biological functions is an area of continuing interest. Poly (Ethylene Glycol) (PEG) is one of the most successfully adopted materials for designing this kind of drug delivery systems and it exhibits a controllable and sustained release profile. Due to its unique structure, PEG molecules are used to reduce the immunogenicity of drug delivery systems and active substances and to avoid unwanted enzymolysis. PEG based copolymers also play a very important role as biomedical materials due to their biocompatibility, biodegradability and easily controllable characters. This mini review summarizes the state-of-the-art use of PEG in therapeutic applications.

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“…However, the uncontrolled swelling and rapid degradation upon storage are two major drawbacks of XG. To overcome these disadvantages and enhance the physicochemical properties and functional features of XG, hydrogels consisting of XG and various natural (chitosan [15,16], N-trimethyl chitosan [17], carboxymethyl chitosan [15], carboxymethyl cellulose [18], alginate [19], starch [20], lignin [21,22]) or synthetic polymers (polyvinylalcohol (PVA) [19,[23][24][25], polyvinylpyrrolidone (PVP) [26], polyethyleneglycol (PEG) [27], poly(acrylic acid) (PAA) [20,26,27]) have been developed.…”

Section: Introductionmentioning

confidence: 99%

Ice-Templated and Cross-Linked Xanthan-Based Hydrogels: Towards Tailor-Made Properties

Rǎschip¹,

Fifere²,

Lazăr³

et al. 2023

Gels

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The use of polysaccharides with good film-forming properties in food packaging systems is a promising area of research. Xanthan gum (XG), an extracellular polysaccharide, has many industrial uses, including as a common food additive (E415). It is an effective thickening agent, emulsifier, and stabilizer that prevents ingredients from separating. Nevertheless, XG-based polymer films have some disadvantages, such as poor mechanical properties and high hydrophilic features, which reduce their stability when exposed to moisture and create difficulties in processing and handling. Thus, the objective of this work was to stabilize a XG matrix by cross-linking it with glycerol diglycidyl ether, 1,4-butanediol diglycidyl ether, or epichlorohydrin below the freezing point of the reaction mixture. Cryogelation is an ecological, friendly, and versatile method of preparing biomaterials with improved physicochemical properties. Using this technique, XG-based cryogels were successfully prepared in the form of microspheres, monoliths, and films. The XG-based cryogels were characterized by FTIR, SEM, AFM, swelling kinetics, and compressive tests. A heterogeneous morphology with interconnected pores, with an average pore size depending on both the nature of the cross-linker and the cross-linking ratio, was found. The use of a larger amount of cross-linker led to both a much more compact structure of the pore walls and to a significant decrease in the average pore size. The uniaxial compression tests indicated that the XG-based cryogels cross-linked with 1,4-butanediol diglycidyl ether exhibited the best elasticity, sustaining maximum deformations of 97.67%, 90.10%, and 81.80%, respectively.

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Formulation and evaluation of polyethylene glycol/Xanthan gum-co-poly (Acrylic acid) interpenetrating network for controlled release of venlafaxine

Cited by 9 publications

References 53 publications

Meta-Analysis of Polyethylene Glycol and Cellulose-based Polymers in Vaccine and Drug Delivery: A Comprehensive Review

Meta-Analysis of Polyethylene Glycol and Cellulose-based Polymers in Vaccine and Drug Delivery: A Comprehensive Review

The Usage of PEG in Drug Delivery Systems- A Mini Review

Ice-Templated and Cross-Linked Xanthan-Based Hydrogels: Towards Tailor-Made Properties

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