Formulation and Evaluation of Sublingual Tablet for Naratripta

Abstract

Naratriptan is used for the treatment of migraine. Formulation and Evaluation of sublingual tablets of Naratriptan for pre and post Compression parameters was undertaken. The tablets were prepared by direct compression method using super disintegrates. After selection of superdisintegrants tablets were prepared by using polymer for reducing the flushing action of saliva and provide enough time for drug absorbed. The prepared tablets were evaluated for their physical and chemical property. The permeation study was performed on Goat mucosa for optimized batch. No interactions were found between drug and excipients. Formulation F2 containing Crosspovidone shows immediate drug release. Formulation F6 containing Chitoson shows fast drug release as compared to superdisintegrants alone. Sublingual tablets were prepared by direct compression method using Crosspovidone as a superdisintegrants. But it is more effective in combination with Chitoson. As a result, sublingual tablet administration of Naratriptan formulated with appropriate excipients and especially with Chitoson seems promising alternative to traditional routes.