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Naratriptan is used for the treatment of migraine. Formulation and Evaluation of sublingual tablets of Naratriptan for pre and post Compression parameters was undertaken. The tablets were prepared by direct compression method using super disintegrates. After selection of superdisintegrants tablets were prepared by using polymer for reducing the flushing action of saliva and provide enough time for drug absorbed. The prepared tablets were evaluated for their physical and chemical property. The permeation study was performed on Goat mucosa for optimized batch. No interactions were found between drug and excipients. Formulation F2 containing Crosspovidone shows immediate drug release. Formulation F6 containing Chitoson shows fast drug release as compared to superdisintegrants alone. Sublingual tablets were prepared by direct compression method using Crosspovidone as a superdisintegrants. But it is more effective in combination with Chitoson. As a result, sublingual tablet administration of Naratriptan formulated with appropriate excipients and especially with Chitoson seems promising alternative to traditional routes.

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A simple, rapid and sensitive spectrofluorimetric method has been developed and validated for the determination of the non-ionic surfactant, polysorbate 80, from pharmaceutical formulation. The proposed method is based on a fluorescence enhancement of the probe (eosin B dye) with addition of polysorbate 80. The eosin B concentration was optimised and found to be 4μg/mL. The fluorescence intensity was measured in a diluting solvent, citric acid buffer (pH 4.0) using excitation and emission wavelengths, 545 nm and 580 nm, respectively. The fluorescence intensity was found to be liner over a concentration range of 16-80 μg/mL of polysorbate 80 with a high correlation coefficient (r = 0.9990). The developed method was validated in terms of linearity, precision, accuracy, limit of detection and limit of quantification and specificity. The limit of detection and limit of quantification for polysorbate 80 were found to be 2 μg/mL and 16 μg/mL, respectively. The developed method was successfully applied for the determination of polysorbate 80 in ophthalmic solution and micro emulsion.