Formulation and Evaluation of Sustained Release Matrix Tablet of Metformin Hydrochloride.

Abstract

Attempt was to formulate the oral sustained release metformin hydrochloride matrix tablets by using hydroxypropyl methylcellulose of (HPMC K-50 M).The tablets were prepared by wet granulation technique. The granules were evaluated for angle of repose, loose bulk density, tapped and bulk density. It shows satisfactory results. The tablets were subjected to thickness, weight variation, drug content, hardness, friability, and in-vitro release studies. In-vitro dissolution profiles of the all formulations were studied in 0.1 N HCl for first 2 hours then 6.8 pH phosphate buffer for next 10 hours using USP dissolution apparatus II (paddle) apparatus. FTIR spectral studies showed that there was no interaction between the drug and excipients. In development of Metformin HCl sustained release tablets was a good approach to sustain the release rate to overcome frequent administration and also to release the drug for a prolong time.