Formulation and Evaluation of Transfersomal Cream of Acriflavine

Chaudhari, Yogesh; Dharashivkar, Sanket; Palkar, Priyanka; Chaudhari, Manisha Y.; Ruhatiya, Gopal; Patil, Mukesh R Hire Lalit V; Gaikwad, Madhuri

doi:10.7897/2230-8407.078100

Cited by 7 publications

(3 citation statements)

References 6 publications

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“…The transfersomes were prepared by the thin-film hydration method and thoroughly evaluated in vitro. The candidate transfersomal formula showed high loading efficiency and prolonged drug release over 24 h [96]. Further research is being undertaken regarding applying transfersome drug delivery systems to burn treatments, as summarized in Table 7.…”

Section: Transfersomesmentioning

confidence: 99%

A Narrative Review of the Potential Roles of Lipid-Based Vesicles (Vesiculosomes) in Burn Management

et al. 2022

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Burn injuries can have a lasting effect on people’s quality of life, as they negatively impact their physical and mental health. Then, they are likely to suffer psychological problems as a result. A serious problem is that deep burns are more challenging to treat due to their slow healing rate and susceptibility to microbial infection. Conventional topical medications used for burn treatment are sometimes ineffective because they cannot optimize their ability of transcutaneous absorption at the targeted site and accelerate healing. However, nanotechnology offers excellent prospects for developing current medical wound therapies and is capable of addressing issues such as low drug stability, water solubility, permeability, and bioavailability. The current review focuses on lipid-based vesicles (vesiculosomes) as an example of advanced delivery systems, showing their potential clinical applications in burn wound management. Vesiculosomes may help overcome impediments including the low bioavailability of active agents, offering the controlled release of drugs, increased drug stability, fewer side effects, and reduced dosing frequency, which will ultimately improve therapeutic efficacy and patient compliance. We discuss the application of various types of vesiculosomes such as liposomes, niosomes, ethosomes, cubosomes, transfersomes, and phytosomes in burn healing therapy, as these demonstrate superior skin penetration compared to conventional burn topical treatment. We also highlight their noteworthy uses in the formulation of natural products and discuss the current status as well as future perspectives of these carriers in burn management. Furthermore, the burn treatment options currently available in the market are also summarized.

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Section: Transfersomesmentioning

confidence: 99%

A Narrative Review of the Potential Roles of Lipid-Based Vesicles (Vesiculosomes) in Burn Management

et al. 2022

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“…In vitro assay for burn wound Improve the sustain release of drug and increase the patient compliance by reducing dose frequency (Chaudhari, 2016).…”

Section: Transfersome Phospholipon G Sodium Cholate and Cholesterol mentioning

confidence: 99%

Current status and future outlook of nano‐based systems for burn wound management

et al. 2019

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Wound healing process is a natural and intricate response of the body to its injuries and includes a well-orchestrated sequence of biochemical and cellular phenomena to restore the integrity of skin and injured tissues. Complex nature and associated complications of burn wounds lead to an incomplete and prolonged recovery of these types of wounds. Among different materials and systems which have been used in treating the wounds, nanotechnology driven therapeutic systems showed a great opportunity to improvement and enhancement of the healing process of different type of wounds. The aim of this study is to provide an overview of the recent studies about the various nanotechnology-based management of burn wounds and the future outlook of these systems in this area. Laboratory and animal models for assessing the efficacy of these systems in burn wound management also discussed. K E Y W O R D S burn wound, laboratory and animal models, multicomposites, nanomedicine, nanotechnologybased systems, nanoparticles, scaffolds

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“…The springback may be controlled through controlling the thickness of sheet metal [7]. Singh and Agnihotri reviewed various parameters and their influences on springback such as friction, blank holding force, punch speed and blank shape [8].…”

Section: Springback In Metal Formingmentioning

confidence: 99%

Springback optimization in automotive Shock Absorber Cup with Genetic Algorithm

Kakandikar¹,

Nandedkar

2018

Manufacturing Rev.

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Abstract. Drawing or forming is a process normally used to achieve a required component form from a metal blank by applying a punch which radially draws the blank into the die by a mechanical or hydraulic action or combining both. When the component is drawn for more depth than the diameter, it is usually seen as deep drawing, which involves complicated states of material deformation. Due to the radial drawing of the material as it enters the die, radial drawing stress occurs in the flange with existence of the tangential compressive stress. This compression generates wrinkles in the flange. Wrinkling is unwanted phenomenon and can be controlled by application of a blank-holding force. Tensile stresses cause thinning in the wall region of the cup. Three main types of the errors occur in such a process are wrinkling, fracturing and springback. This paper reports a work focused on the springback and control. Due to complexity of the process, tool try-outs and experimentation may be costly, bulky and time consuming. Numerical simulation proves to be a good option for studying the process and developing a control strategy for reducing the springback. Finite-element based simulations have been used popularly for such purposes. In this study, the springback in deep drawing of an automotive Shock Absorber Cup is simulated with finite element method. Taguchi design of experiments and analysis of variance are used to analyze the influencing process parameters on the springback. Mathematical relations are developed to relate the process parameters and the resulting springback. The optimization problem is formulated for the springback, referring to the displacement magnitude in the selected sections. Genetic Algorithm is then applied for process optimization with an objective to minimize the springback. The results indicate that a better prediction of the springback and process optimization could be achieved with a combined use of these methods and tools.

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Formulation and Evaluation of Transfersomal Cream of Acriflavine

Cited by 7 publications

References 6 publications

A Narrative Review of the Potential Roles of Lipid-Based Vesicles (Vesiculosomes) in Burn Management

A Narrative Review of the Potential Roles of Lipid-Based Vesicles (Vesiculosomes) in Burn Management

Current status and future outlook of nano‐based systems for burn wound management

Springback optimization in automotive Shock Absorber Cup with Genetic Algorithm

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