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Silver sulfadiazine (SSD) is the antibacterial of choice for the treatment of burn. The current marketed formulation of SSD is 1% w/w water soluble cream, which requires frequent applications, which is very painful to patients. Niosomes were prepared by a thin film hydration method. The in vitro antimicrobial efficiency of niosomal SSD (18 ± 0.5 mm) was as good as that of marketed cream (17 ± 0.5 mm) against Staphylococcus aureus even when used in half the concentration (0.5%) of marketed cream (1%). Further SSD (0.5% w/w) niosomal gel was prepared using 1.6% carbopol 934. It was evident through in vitro permeation studies that SSD release was considerably retarded from both niosomes and niosomal gel in comparison with marketed cream thereby decreasing the dosing frequency. In-vivo study demonstrated that a niosomal gel containing 0.5% w/w SSD was more effective in burn wound healing compared to 1% w/w marketed cream even when applied once a day.

A burn can be major medical problems or life-threatening emergencies admitted to any hospital. Conventional topical burn formulations are required to be applied 3 to 4 times a day and previous application is needed to be removed prior to application of each new dose which is very painful to burn patients. In this research an attempt was made to increase the patient compliance by reducing the dosing frequency through sustained release vesicular drug delivery system like transfersomes. Transfersomes were formulated using by thin film hydration method and evaluated for entrapment efficiency, photomicroscopy, scanning electron microscopy, vesicle size, polydispersity and zeta potential. Optimized Transfersomal batch was incorporated in cream base and evaluated for pH, spreadability, viscosity, drug content and in vitro diffusion. Transfersomes prepared by using 1:3 ratio of sodium cholate with cholesterol and 200 mg drug showed highest entrapment (91.65%) and sustained release (65.18% in was 24 hrs) was obtained with transfersomal cream in comparison with conventional formulation (97.54% in 8 hrs).

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Background: In the present research work transferosomal gel was developed for an effective treatment of skin infection using cephalexin as model drug. The Transferosomes were prepared by thin film hydration method using Phospholipon 90H as a Lipid, Sodium deoxycholate as a surfactant and the vesicles were characterized on the basis of entrapment efficiency, particle size, Zeta potential, shape, morphology, x-ray diffraction analysis and in-vitro drug release. The transfersomal gel was prepared by dispersion method using Carbopol 934 as a gelling agent and evaluated for spreadability, viscosity, pH, drug release, antimicrobial study and stability.Results: The entrapment efficiency of the optimized transferosomes was found to be 90.62% and the % Cumulative release of gel across the dialysis membrane was found to be 91.26% at the end of 24h. Conclusion: Vesicular system can be of great help in decreasing the burden of Bacterial infections and other infections around the globe.