Formulation and in Vitro Evaluation of Salbutamol Sulphate and Theophylline Extended-Release Tablets Using Modified Polymers

Goyal, Nupur; Kumar, Anil

doi:10.22159/ijpps.2018v10i8.27865

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Fourier-transform infrared of dalfampridine tablets of both the drugs[9]. The test was carried out using USP XXI Dissolution Testing Apparatus Type II, (Electrolab, India) using 900 ml of pH 6.8 phosphate buffer maintained at 37±0.5°C as medium.…”

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confidence: 99%

Assessment of Self-Extracted Cellulose From Oryza Sativa for Design of Controlled Drug Delivery System of Dalfampridine

Mounika

2019

Asian J Pharm Clin Res

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Objectives: The main objective of the present work includes extraction of cellulose from Oryza sativa (OS), characterization of cellulose, development of controlled release tablet dalfampridine using cellulose of OS, and in vitro evaluation. Methods: Dry powdered OS husk sample was extracted with a mixture of hexane and methanol (2:1, v/v) using soxhlation method and was characterized by solubility, melting point determination, differential scanning calorimetry (DSC), and Fourier-transform infrared (FTIR) analysis. Compatibility between dalfampridine and the mixture of cellulose with dalfampridine was confirmed by FTIR and DSC analysis. Then, controlled drug delivery system of dalfampridine were prepared as directly compressed tablets using various compositions containing OS cellulose, hydroxypropyl methylcellulose (HPMC), dicalcium phosphate, and magnesium stearate (8 nos. F1 to f8) and were evaluated. Results: Cellulose was extracted from OS extract to possess its ideal characteristics. Dalfampridine and its mixture with cellulose were compatible according to FTIR and DSC analysis. Directly compressed tablets made with 10 mg of dalfampridine and OS cellulose, HPMC, dicalcium phosphate, and magnesium stearate evidenced prolonged and controlled drug delivery of dalfampridine for 12 h. Formulation made with OS cellulose 250 mg, HPMC 20 mg, dicalcium phosphate 40 mg, and magnesium stearate 5 mg was ideal without burst release. Conclusion: Cellulose extracted from OS is used successfully for the production of directly compressed tablets of dalfampridine to elicit optimum characteristics including controlled drug delivery for 12 h.

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Assessment of Self-Extracted Cellulose From Oryza Sativa for Design of Controlled Drug Delivery System of Dalfampridine

Mounika

2019

Asian J Pharm Clin Res

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“…The prepared core tablets were subjected to compression coating by using various compositions of polymers such as Ethylcellulose, Eudragit L 100 and Eudragit S 100 as coating materials [8,9]. The composition of coating layer is given in below table 2.…”

Section: Formulation Of Compression Coated Tabletsmentioning

confidence: 99%

Formulation and in Vitro Evaluation of Ramelteon Tablets for Colon Drug Delivery System by Compression Coating

Rao¹,

Parimala²,

Yamini³

et al. 2021

Int J App Pharm

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Objective: Ramelteon, is a sleep agent that selectively binds to the MT1 and MT2 receptors in the suprachiasmatic nucleus (SCN), instead of binding to GABAA receptors. In the present research work, the formulation of ramelteon targeted to colon by using various polymers developed. Methods: Colon-targeted tablets were prepared in two steps. Initially, core tablets were prepared and then the tablets were coated by using different pH dependent polymers. Ethylcellulose, Eudragit RLPO and L100 were used as enteric coating polymers. The precompression blend of all formulations was subjected to various flow property tests and all the formulations were passed the tests. The tablets were coated by using polymers and the coated tablets were subjected to physical characterization, drug content, in vitro drug release and kinetics of drug release. Results: Among all the formulations, F4 formulation was found to be optimized as it was retarded the drug release up to 18 h and showed maximum of 99.25% drug release. It followed the first-order kinetics mechanism. All the formulations having Korsmeyer-Peppas ‘n’ values are in the range of 0.540 to 0.818. Hence, it was concluded that the prepared formulations followed non-Fickian diffusion. Conclusion: An effective and stable remelteon colon targeted formulation developed for treating insomnia.

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Nanogel-based Transdermal Drug Delivery System: A Therapeutic Strategy with Under Discussed Potential

Tariq

Arafah

Ali

et al. 2023

CTMC

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The application of nanoparticles in medication delivery has revolutionized the field of therapeutic biology. To improve medical efficacy, currently, drug nanocarriers are employed to control the release and stability, expand its circulation time, or protect it from cell clearance or premature breakdown. A crosslinked polymeric framework is used to crosslink the hydrogel nanoparticle dispersions for safer and stable delivery on target sites. Nanogels have developed in the last two decades as potential biomaterials with a wide variety of applications. Later attributes of nanogels are mainly due to large surface areas, retention of molecules, size flexibility, and water-based formulations that have made them popular as drug delivery vehicles, as seen by several in vivo uses. The gel matrix containing the nanoparticle drug demonstrated a considerable increase in drug penetration in transdermal drug and topical delivery methods. This review aims to understand why and how nanogels are considered so innovative as a drug delivery method. It also examines their preparation methods and applications in the pharmaceutical and biomedical fields and discusses the benefits of nanogels, including swelling capacity and stimulus stimuli sensitivity. Nanogels, on the other hand, have recently been investigated for applications outside the field of biomedicine. Since there are many possible uses for nanogels, we have comprehensively reviewed the current state of the art for all feasible nanogel applications and manufacturing methods.

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Formulation and in Vitro Evaluation of Salbutamol Sulphate and Theophylline Extended-Release Tablets Using Modified Polymers

Cited by 4 publications

References 6 publications

Assessment of Self-Extracted Cellulose From Oryza Sativa for Design of Controlled Drug Delivery System of Dalfampridine

Assessment of Self-Extracted Cellulose From Oryza Sativa for Design of Controlled Drug Delivery System of Dalfampridine

Formulation and in Vitro Evaluation of Ramelteon Tablets for Colon Drug Delivery System by Compression Coating

Nanogel-based Transdermal Drug Delivery System: A Therapeutic Strategy with Under Discussed Potential

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