Formulation and In-vitro Evaluation of Bilayer Tablets of Atenolol and Amlodipine

Sikdar, KM Yasif Kayes; Ahamed, Ahad; Alam, M. M. Mahbub; Sarkar, Md. Raihan; Sajeeb, BK

doi:10.3329/bpj.v22i2.42299

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…FT-IR is a drug characterizing technique that helps to find out the drug-excipient interactions as well as the stability of the drug in a solid dispersion formulation (Miyazaki et al, 2011). The scanning resolution of FT-IR was performed at 1 cm -1 over the region of 4000-500 cm -1 (Sikdar et al, 2019). After analyzing, there were no significant shifts in the FT-IR peaks.…”

Section: Characterization Of the Best Formulationmentioning

confidence: 99%

Enhancement of dissolution profile of poorly aqueous soluble atorvastatin calcium by binary and ternary solid dispersion techniques

Sarkar¹,

Hossin²,

Hossain³

et al. 2021

Bangladesh J. Sci. Ind. Res.

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Atorvastatin calcium (ATV) is an HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase inhibitor commonly known as a cholesterol-lowering agent. As a poorly water-soluble drug its absolute bioavailability is very low. To increase the water solubility as well as oral bioavailability, different hydrophilic carriers were used in different ratios (1:0.5, 1:1 and 1:2) to prepare reproducible binary and ternary solid dispersion formulations of ATV by simple physical mixing (PM) and fusion or melting technique. In vitro dissolution studies results revealed that in all cases, the cumulative percent drug release from ATV ternary SD formulations were greater than binary formulations, some marketed products and pure ATV powder. The order of the carriers in enhancing the drug release was found as kollidon 90F > pregelatinized starch > lutrol> kollidon 12F (99.1%, 98.8%, 96% and 95% respectively) for ternary SD formulations whereas pure ATV powder and marketed products showed cumulative percentage release 70.8%, 68.9% (B1) and 73.1% (B2), respectively. The best-out performed ternary SD formulation ATV:Kollidon 90 F (1:2) were further characterized using FT-IR and SEM. SEM analyses indicated conversion of crystal drug to amorphous form and FT-IR data suggested that little or no interaction between the drug and polymer. Bangladesh J. Sci. Ind. Res.56(3), 165-176, 2021

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Section: Characterization Of the Best Formulationmentioning

confidence: 99%

Enhancement of dissolution profile of poorly aqueous soluble atorvastatin calcium by binary and ternary solid dispersion techniques

Sarkar¹,

Hossin²,

Hossain³

et al. 2021

Bangladesh J. Sci. Ind. Res.

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“…(5) Hixson-Crowell model -(Cube root of initial amount -Cube root of drug remaining) versus time (T) (Sikdar et al, 2019).…”

Section: Kinetic Data Analysismentioning

confidence: 99%

Comparative Evaluation of Bromhexine HCl Mucoadhesive Microspheres Prepared by Anionic, Cationic and Nonionic Polymers

2020

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The purpose of this study was to formulate and assess the mucoadhesive microspheres of bromhexine hydrochloride, a mucolytic agent, using three different types of polymers to achieve gastric retention for improved solubility and bioavailability of the drug. The mucoadhesive formulation was prepared because it dissolved in the pH range of 1 to 4. The characteristics of the prepared microspheres were evaluated by determining the particle size, percent drug loading, surface morphology, swelling behavior, mucoadhesive bond strength and drug entrapment efficiency. The in vitro dissolution was studied using the USP dissolution apparatus I in 0.1N HCl (pH 1.2) media for 8 hours. The release kinetics were analyzed by using zero order, first order, Higuchi, Korsmeyer-Peppas and Hixon-crowell equations to explain the release mechanism from the microspheres. The microspheres exhibited good swelling index and the drug entrapment efficiency was above 79 % for all the formulations. All the formulations showed drug release above 25%, 35%, 50% and 75% after 2 hrs, 4 hrs, 6 hrs and 8 hrs of dissolution respectively. The mucoadhesive bond was observed up to 8 hrs in acidic media. The surface morphology of the prepared microspheres was studied by Scanning Electron Microscope (SEM) and no interaction was found between drug and polymer from the FTIR study. Bangladesh Pharmaceutical Journal 23(2): 117-124, 2020

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“…The experimental formulations were undergone compatibility studies by using FTIR tactic. The scanning resolution was 1 cm -1 over the region of 4000-600 cm −1 [8].…”

Section: Compatibility Studies By Ftirmentioning

confidence: 99%

A comparative study on Naproxen Sodium tablets formulating with different super disintegrants

Kayes

Molla

Hamidur

et al. 2019

GSC Biol. and Pharm. Sci.

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Naproxen, a commonly used non-steroidal anti-inflammatory drug (NSAID), for pain management and immediate release tablet is more patient convenient for managing pain immediately. In this study, six different formulations (F1-F6) of naproxen immediate release tablets were prepared by wet granulation method and were designed to increase disintegration and drug release property by using two super disintegrants named sodium starch glycolate and crospovidone in different concentrations. After preparing the formulations, the physicochemical properties were evaluated according to the United States Pharmacopoeia (USP) guideline. Among all the formulations, F6 proved to be the best immediate release formulation in terms of disintegration time (1.23 min) and dissolution (99.56% after 30 minutes). Other tablet properties of formulation F6 like average weight, diameter, thickness, hardness and friability were also within the USP limit. Drug release kinetics were analyzed through different models such as zero order, first order, Higuchi, Korsmeyer-Peppas and Hixson-Crowell model where the optimized formulation (F6) was best fitted in Hixson-Crowell model. The release mechanism of naproxen followed non-swellable matrix-diffusion, Quasi-Fickian diffusion. Moreover, F6 formulation was stable at 45 °C/ 75% RH for a period of three months and compatibility study was conducted by using Fourier Transform Infrared Spectroscopy (FTIR) where no change was found in stability and peak positions. The optimized formulation (F6) was compared with eight (8) different naproxen immediate release tablet brands (B1-B8) available in market based on dissolution. F6 showed better release property than the marketed tablets. Thus, it can be comprehended that the formulation F6 was robust and stable with a better immediate release property.

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Formulation and In-vitro Evaluation of Bilayer Tablets of Atenolol and Amlodipine

Cited by 4 publications

References 9 publications

Enhancement of dissolution profile of poorly aqueous soluble atorvastatin calcium by binary and ternary solid dispersion techniques

Enhancement of dissolution profile of poorly aqueous soluble atorvastatin calcium by binary and ternary solid dispersion techniques

Comparative Evaluation of Bromhexine HCl Mucoadhesive Microspheres Prepared by Anionic, Cationic and Nonionic Polymers

A comparative study on Naproxen Sodium tablets formulating with different super disintegrants

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