Formulation aspects in the development of osmotically controlled oral drug delivery systems

Formulation and Evaluation of Osmotically Controlled Release Tablets of Tramadol Hydrochloride

“…As new innovation in oral controlled plasma drug delivery it avoids fluctuation in drug concentration and offers better drug utilization and patient compliance.So in the present study attempt has been made to control the release of Tramadol hydrochloride by two different approaches i.e. one using osmotic agents and other by changing the orifice size [2][3][4][5][6][7][8][9][10] . A semi permeable micro porous membrane that regulates the drug release surrounds the system.…”

Emerging pressure-release materials for drug delivery

“…Because mechanical deformation of gels is a simple matter, pressure-induced control of drug release from gel materials is also possible. Osmotic pressure has widely been used for controlling drug release from gel matrices, and many commercial products are already available [13]. However, drug release based on simple volume changes (i.e., swelling and shrinkage) may not provide highly specific drug release.…”

Liberação específica de fármacos no cólon por via oral. II - Tipos de sistemas utilizados

“…A liberação de fármacos a partir deste sistemas é independente de fatores fisiológicos do trato gastrointestinal. Ao modificar alguns fatores de formulação, como a solubilidade e pressão osmótica dos componentes do núcleo, o tamanho do orifício e a natureza da membrana que controla a entrada de água no sistema podem obter-se diferentes tempos de latência (Verma et al, 2002). O OROS-CT ® foi concebido para provocar um atraso pós-gástrico de 3 a 4 horas, evitando que a liberação ocorra no intestino delgado (Tweeuwes et al, 1993 …”