Emerging pressure-release materials for drug delivery

Ariga, Katsuhiko; Kawakami, Kenji; Hill, Jonathan P.

doi:10.1517/17425247.2013.819340

Cited by 18 publications

(7 citation statements)

References 16 publications

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“…Based on lowest droplet size 64.7 nm , lowest PI 0.112 , lowest viscosity 35.6 cp , highest T 99.1 , highest drug content 98. 9 , lower concentration of Capryol-90 8 w/w , optimum surfactant Triton-X100, 20 w/w & cosurfactant concentrations Transcutol-HP, 20 w/w and highest drug release 96. 6 , SNEDDS F5 has been optimized as an effective formulation of tadalafil.…”

Section: Discussionmentioning

confidence: 95%

Solubility and Dissolution Enhancement of Tadalafil Using Self-Nanoemulsifying Drug Delivery System

et al. 2014

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The aim of this study was to develop and evaluate self-nanoemulsifying drug delivery system (SNEDDS) of tadalafil (TDL) in order to enhance its aqueous solubility and dissolution rate. TDL SNEDDS were developed by aqueous phase titration method via construction of pseudo-ternary phase diagrams. The formulations which passed thermodynamic stability and self-nanoemulsification tests were further characterized in terms of droplet size, viscosity, % transmittance and drug content. Selected SNEDDS and drug suspension were subjected to in vitro drug release studies via dialysis membrane in phosphate buffer (pH 6.8). In vitro drug release studies showed 96.6% release of TDL from optimized SNEDDS F5 as compared to only 12.4% from drug suspension after 24 h of study. The results of solubility studies showed 1434 folds enhancement in TDL solubility from optimized SNEDDS F5 as compared to its aqueous solubility. Overall, these results indicated that developed SNEDDS could be successfully used to enhance solubility and dissolution rate of poorly soluble drugs such as TDL.

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Section: Discussionmentioning

confidence: 95%

Solubility and Dissolution Enhancement of Tadalafil Using Self-Nanoemulsifying Drug Delivery System

et al. 2014

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“…Examples of advantages of this technique over traditional methods include: 1) enhancing solubility (and hence bioavailability) of poorly soluble drugs by molecularly dispersing the drug within the polymer matrix, 2) processing is environmentally friendly since no organic solvents or water are used, 3) it lends itself to a continuous and less labor intensive process, which is amenable to Quality by Design (QbD) and Process Analytical Techniques (PAT), and 4) it is considered as a promising method to manufacture scalable products. Other delivery systems such as polymeric nanoparticles [22], enzyme nanoarchitectonics [23], carbon nanotubes [24] and pressure-release drug delivery [25], although novel, are not all necessarily scalable. However, few researchers have demonstrated that HME techniques are a viable method to prepare novel, scalable delivery systems via extruded films.…”

Section: Introductionmentioning

confidence: 99%

Development of an antifungal denture adhesive film for oral candidiasis utilizing hot melt extrusion technology

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Prodduturi

Morott

et al. 2014

Expert Opinion on Drug Delivery

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Objectives The overall goal of this research was to produce a stable hot-melt extruded “Antifungal Denture Adhesive film” (ADA) system for the treatment of oral candidiasis. Methods The ADA systems with hydroxypropyl cellulose (HPC) and/or polyethylene oxide (PEO) containing clotrimazole (10%) or nystatin (10%) were extruded utilizing a lab scale twin-screw hot-melt extruder. Rolls of the antifungal-containing films were collected and subsequently die-cut into shapes adapted for a maxillary (upper) and mandibular (lower) denture. Results DSC and PXRD results indicated that the crystallinity of both APIs was changed to amorphous phase after hot-melt extrusion. The ADA system, containing blends of HPC and PEO, enhanced the effectiveness of the antimicrobials a maximum of 5-fold toward the inhibition of cell adherence of C. albicans to mammalian cells/Vero cells. Remarkably, a combination of the two polymers without drug also demonstrated a 38% decrease in cell adhesion to the fungi due to the viscosity and the flexibility of the polymers. Drug-release profiles indicated that both drug concentrations were above the minimum inhibitory concentration (MIC) for C. albicans within 10 minutes and was maintained for over 10 hours. In addition, based on the IC50 and MIC values, it was observed that the antifungal activities of both drugs were increased significantly in the ADA systems. Conclusions Based on these findings, the ADA system may be used for primary, prophylaxis or adjunct treatment of oral or pharyngeal candidiasis via controlled-release of the antifungal agent from the polymer matrix.

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“…Hand manipulation for drug delivery for use in any situation will create various possibilities in many medical opportunities. 73…”

Section: Emerging Challenge 2: Control By Hand Operationmentioning

confidence: 99%

Bioinspired nanoarchitectonics as emerging drug delivery systems

et al. 2014

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Emerging pressure-release materials for drug delivery

Cited by 18 publications

References 16 publications

Solubility and Dissolution Enhancement of Tadalafil Using Self-Nanoemulsifying Drug Delivery System

Solubility and Dissolution Enhancement of Tadalafil Using Self-Nanoemulsifying Drug Delivery System

Development of an antifungal denture adhesive film for oral candidiasis utilizing hot melt extrusion technology

Bioinspired nanoarchitectonics as emerging drug delivery systems

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