Formulation design and in vitro physicochemical characterization of surface modified self-nanoemulsifying formulations (SNEFs) of gentamicin

Umeyor, Chukwuebuka; Attama, Anthony A.; Uronnachi, Emmanuel; Kenechukwu, Franklin Chimaobi; Nwakile, Calistus; Nzekwe, Ifeanyi T.; Okoye, Eric; Esimone, Charles Okechukwu

doi:10.1016/j.ijpharm.2015.10.033

Cited by 17 publications

(8 citation statements)

References 32 publications

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“…Among the self-emulsifying formulation systems, self-nanoemulsifying drug delivery systems (SNEDDS) are relatively more in demand technologically, which have shown to reduce the slow, and incomplete drug dissolution and facilitate the formation of its solubilized phase that are highly potent for systemic absorption (Umeyor et al, 2016a, Umeyor et al, 2016b). Primarily, SNEDDS is a liquid isotropic mixtures of active pharmaceutical drug in a combination of lipids, surfactants and water soluble co-solvents, which can be solidified as solid SNEDDS.…”

Section: Introductionmentioning

confidence: 99%

Novel oral dosage regimen based on self-nanoemulsifying drug delivery systems for codelivery of phytochemicals – Curcumin and thymoquinone

Alwadei

Kazi

Alanazi

2019

Saudi Pharmaceutical Journal

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Graphical abstractCurcumin (CUR) and Thymoquinone (THQ) were formulated using self-nanoemulsifying drug delivery systems (SNEDDS) as combined dosage form. The solubility, stability and drug release in dissolution media were significantly improved by the SNEDDS formulation compare to the raw drug powder.Schematic Diagram: Dosage form design and CUR & THQ release after oral administration of lipid-based SNEDDS formulations.

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Section: Introductionmentioning

confidence: 99%

Novel oral dosage regimen based on self-nanoemulsifying drug delivery systems for codelivery of phytochemicals – Curcumin and thymoquinone

Alwadei

Kazi

Alanazi

2019

Saudi Pharmaceutical Journal

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“…Thereafter, samples were visually examined for clarity and classified as clear nanoemulsion or emulsion. The phase behaviour of the disperse systems was represented on ternary phase diagrams with three apices: Conophor oil, water, and T80+PEG 400 (Smix) using ProSim software 23 .…”

Section: Construction Of Ternary Phase Diagramsmentioning

confidence: 99%

Lipid Nanoemulsion-Based Liquisolid Compact Tablets for Oral Delivery of Clotrimazole: Fabrication Strategies, Characterizations, Antimycotic and Toxicological Evaluations

Umeyor

Ezechukwu²,

Okafor³

et al. 2022

Bulletin of Pharmaceutical Sciences. Assiut

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This work aims to fabricate liquisolid compact tablets incorporating clotrimazole (CLOT)loaded lipid nanoemulsions (LNE) for oral treatment of systemic fungal infections.Nanoemulsion was characterized for droplet size, rendered into free-flowing granules and compressed into liquisolid compact tablets, and evaluated using pharmacopoeial and nonpharmacopoeial methods. In-vitro and in vivo antifungal, stability and toxicological tests of the tablets were evaluated. . Liquisolid tablets were stable, non-toxic, had uniform weight (341.4 ± 1.2 -346.7 ± 0.8 mg), drug content uniformity (85.2 ± 0.1 -99.8 ± 0.2 %), and had excellent disintegration (2.96 ± 0.8 -5.88 ± 1.3 min), and controlled release property. In-vitro and in vivo antifungal evaluations revealed improved antimycotic activity of CLOT. The results highlight that CLOT-LNE liquisolid compact tablets is a promising carrier system with improved oral utility for the treatment of systemic fungal infections.

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“…39 Polyethylene glycol (PEG) coating, on the other hand, imbues the nanoparticles with an electrically neutral and hydrophilic surface, and therefore can prevent the hydrophobic and electrostatic interactions between the nanoparticles and the mucus layer. 46,47…”

Section: Dovepressmentioning

confidence: 99%

<p>Recent Advances in Oral Nano-Antibiotics for Bacterial Infection Therapy</p>

Wu¹,

Zhao²,

Xu³

2020

IJN

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Bacterial infections are the main infectious diseases and cause of death worldwide. Antibiotics are used to treat various infections ranging from minor to life-threatening ones. The dominant route to administer antibiotics is through oral delivery and subsequent gastrointestinal tract (GIT) absorption. However, the delivery efficiency is limited by many factors such as low drug solubility and/or permeability, gastrointestinal instability, and low antibacterial activity. Nanotechnology has emerged as a novel and efficient tool for targeting drug delivery, and a number of promising nanotherapeutic strategies have been widely explored to overcome these obstacles. In this review, we explore published studies to provide a comprehensive understanding of the recent progress in the area of orally deliverable nanoantibiotic formulations. The first part of this article discusses the functions and underlying mechanisms by which nanomedicines increase the oral absorption of antibiotics. The second part focuses on the classification of oral nano-antibiotics and summarizes the advantages, disadvantages and applications of nanoformulations including lipid, polymer, nanosuspension, carbon nanotubes and mesoporous silica nanoparticles in oral delivery of antibiotics. Lastly, the challenges and future perspective of oral nano-antibiotics for infection disease therapy are discussed. Overall, nanomedicines designed for oral drug delivery system have demonstrated the potential for the improvement and optimization of currently available antibiotic therapies.

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Formulation design and in vitro physicochemical characterization of surface modified self-nanoemulsifying formulations (SNEFs) of gentamicin

Cited by 17 publications

References 32 publications

Novel oral dosage regimen based on self-nanoemulsifying drug delivery systems for codelivery of phytochemicals – Curcumin and thymoquinone

Novel oral dosage regimen based on self-nanoemulsifying drug delivery systems for codelivery of phytochemicals – Curcumin and thymoquinone

Lipid Nanoemulsion-Based Liquisolid Compact Tablets for Oral Delivery of Clotrimazole: Fabrication Strategies, Characterizations, Antimycotic and Toxicological Evaluations

<p>Recent Advances in Oral Nano-Antibiotics for Bacterial Infection Therapy</p>

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