2015
DOI: 10.4155/tde.14.106
|View full text |Cite
|
Sign up to set email alerts
|

Formulation Design for Topical Drug and Nanoparticle Treatment of Skin Disease

Abstract: The skin has evolved to resist the penetration of foreign substances and particles. Topical therapeutic and cosmeceutical delivery is a growing field founded on selectively overcoming this barrier. Both the biology of the skin and the nature of the formulation/active ingredient must be aligned for efficient transcutaneous delivery. This review discusses the biological changes in the skin barrier that occur with common dermatological conditions. This context is the foundation for the discussion of formulation s… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
13
0

Year Published

2016
2016
2024
2024

Publication Types

Select...
7
1
1
1

Relationship

3
7

Authors

Journals

citations
Cited by 27 publications
(13 citation statements)
references
References 110 publications
0
13
0
Order By: Relevance
“…In the past decade, nanoparticle formulations have been developed as novel topical drug delivery systems that can effectively improve the poor solubility of therapeutic and other active agents, enabling them to penetrate the stratum corneum via intercellular, intracellular, and transappendageal pathways for the treatment of skin diseases. 50 Eupafolin, a flavonoid compound, is purified from P. nodiflora, and its flavone backbone structure displays poor water solubility and limits its skin absorption after topical administration. Our results demonstrated that ENDS can be successfully prepared by the nanoprecipitation method and can overcome the poor water solubility and skin penetration of raw eupafolin.…”
Section: Discussionmentioning
confidence: 99%
“…In the past decade, nanoparticle formulations have been developed as novel topical drug delivery systems that can effectively improve the poor solubility of therapeutic and other active agents, enabling them to penetrate the stratum corneum via intercellular, intracellular, and transappendageal pathways for the treatment of skin diseases. 50 Eupafolin, a flavonoid compound, is purified from P. nodiflora, and its flavone backbone structure displays poor water solubility and limits its skin absorption after topical administration. Our results demonstrated that ENDS can be successfully prepared by the nanoprecipitation method and can overcome the poor water solubility and skin penetration of raw eupafolin.…”
Section: Discussionmentioning
confidence: 99%
“…The physical stability of the product is related to the physical form of the preparation such as sedimentation, creaming, flocculation, coalescence, and phase separation [2]. Physical stability of the preparations can be enhanced by physical development, such as the use of solid lipid nanoparticles (SLNs) [3].…”
Section: Introductionmentioning
confidence: 99%
“…Another important aspect is that they can be produced using more practical surfactant concentrations, e.g., 5%, when compared to ~50%, which is typically used to prepare microemulsions [ 13 ]. Accordingly, submicron and nanoemulsions have gained increasing attention as drug delivery systems for oral, parenteral, transdermal, and topical (e.g., dermo-cosmetic, vitamins, and anti-aging agents) applications [ 14 , 15 , 16 , 17 ]. Recent progress in the control of size distribution and in the understanding of stabilization mechanisms of nanoemulsion has also contributed to renewed attention to these particular emulsion systems [ 18 , 19 ].…”
Section: Introductionmentioning
confidence: 99%