Formulation development and characterization

Dezfooli, Seyedehsara Masoomi; Dkhar, Lari; Long, Abbey; Gholizadeh, Hamideh; Mohammadi, Soniya; Greene, Carol Ann; Seyfoddin, Ali

doi:10.1016/b978-0-08-102548-2.00003-2

Cited by 2 publications

(2 citation statements)

References 117 publications

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“…Dry in the oven at 1000 c or 1050 c. Cool in a desiccator and watch. The loss in weight is recorded as moisture 30 .…”

Section: Animals Housing and Feeding Conditionsmentioning

confidence: 99%

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2023

IJPSR

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Herbal medicine (also herbalism) is the study of pharmacognosy and the use of medicinal plants, which are the basis of traditional medicine. Any damage or break in the surface of the skin is a wound. In Soxhlet extraction, solvent extraction involves extraction with solvents of increasing polarity from a nonpolar to a more polar solvent to ensure that a wide polarity range of compounds can be extracted. 1 % of the extract was incorporated in the preparation of gel formulation using Carbomer 940 polymer as gelling agent. Three formulae 1, 2 and 3 of gel containing varying concentrations of Carbomer 940(0.5, 1 and 1.5%) were prepared. Carbomer 940 was soaked in distilled water overnight. Selected extracts were dissolved in ethanol. Standard methods and results examined different Physicochemical evaluation parameters of formulated ointments were found within the acceptable limits. Cissampelos Pareira Vein-islet number/mm 2 was 3.6 and it ranges from 3.5 to 3.9. The Palisade ratio was 3, and it ranges from 2.75 to 3.75. The Stomata length (µm) was found to be 20.5 and it ranges from 18.1 to 22.7. Hence we can conclude from our findings that the developed formulations containing bioactive Methanol extracts of Cissampelos Pareira and Bergenia ciliate formulation acted on each component of the wound healing process.

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“…Dry in the oven at 1000 c or 1050 c. Cool in a desiccator and watch. The loss in weight is recorded as moisture 30 .…”

Section: Animals Housing and Feeding Conditionsmentioning

confidence: 99%

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2023

IJPSR

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“…Drug research focuses on improving controlled release and specific targeting. Nanoparticles (NPs) are encapsulation systems used to improve therapeutic agent efficacy, such as antiviral agents, anticancer agents, or diagnostic [ 12 , 13 ], with minimal toxicity. For this reason, the design and development of methods that can effectively generate these NPs are required.…”

Section: Introductionmentioning

confidence: 99%

Insight into the Antioxidant Activity of Ascorbic Acid-Containing Gelatin Nanoparticles in Simulated Chronic Wound Conditions

Morán,

Porredon,

Gibert

2024

Antioxidants

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Chronic wounds differ from acute wounds by remaining in the inflammatory phase for a long time. This chronic inflammation confers a high concentration of inflammatory cytokines, proteases, and ROS. Likewise, the pH environment of chronic wounds has been recorded within the range of 7.2–8.9 due to the alkaline by-products of bacterial proliferation. In this work, differences in pH between healthy skin and chronic cutaneous wounds have been used for the design and development of pH-responsive gelatin-based nanoparticles (NPs). Ascorbic acid (AA), as an antioxidant compound that can neutralize reactive oxygen species (ROS), has been the therapeutic model compound included in these NPs. The goal of the present work has been the preparation and characterization (physicochemical and biological properties) of NPs for the effective release of AA under simulated chronic wound conditions. In vitro experiments demonstrated total AA release at pH corresponding to the chronic wounds. The biocompatible character of these gelatin-based NPs based on their hemolytic and cytotoxicity responses has been highlighted under in vitro conditions. The reversible and protective antioxidant properties of the AA-including NPs in erythrocytes and skin cell lines, respectively, have been confirmed to be modulated by the gelatin A gel strength.

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Formulation development and characterization

Cited by 2 publications

References 117 publications

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Insight into the Antioxidant Activity of Ascorbic Acid-Containing Gelatin Nanoparticles in Simulated Chronic Wound Conditions

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