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This review article highlights the importance and advantages of the drug delivery systems applied via the nasal route after endoscopic sinus surgery (ESS) for patients suffering from chronic rhinosinusitis (CRS). After ESS, patients often require ongoing topical and systemic medication. To reduce the incidence of immediate and delayed post-surgical complications, a variety of temporary post-operative nasal interventions are currently used. However, newly developed intranasal drug delivery devices can enhance tissue recovery after ESS by releasing therapeutic drugs locally, while providing structural support to reduce tissue adhesion and scaring. Intranasal drug delivery devices are promising next generation post-surgery devices, offering advantages for enhancing tissue recovery through release of loaded therapeutic drugs locally in a controlled manner over the required time-frame during post-operative healing. The mechanisms and effectiveness of these drug delivery systems initiate a new era in providing topical controlled drug delivery to the sinus tissue and can be a guide for the future development of specific effective therapies of preparations with other drugs that otherwise should be administered parenterally. Hence, further research is required to validate their efficacy.

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