Acrylic acid/acrylamide based hydrogels and its properties - A review

Sennakesavan, Gangadevi; Mostakhdemin, Mohammad; Dkhar, Lari; Seyfoddin, Ali; Januddi, Fatihhi

doi:10.1016/j.polymdegradstab.2020.109308

Cited by 221 publications

(115 citation statements)

References 69 publications

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“…The mobility and relaxation of the polymeric chains are prevented by an increase of the cross-linking degree, which prevent water mobility and consequently decrease the Rs values [ 90 ]. Water retention, Wr , can be obtained from Equation (2):

where Wt represents the complexive mass of the hydrogels, at a defined time interval, Ws and Wd represent the hydrogel weight in the swollen and dried state, respectively [ 91 ]. Another theory that explains the swelling behavior of a hydrogel is the one proposed by Flory–Rehner, using Gibbs free energy, about equilibrium swelling theory [ 92 ].…”

Section: Sanitizing Hydrogels: Properties and Characterizationmentioning

confidence: 99%

“…Hydrogels present mechanical properties that can be considered significant parameters for several biomedical applications in particular in drug delivery and tissue engineering [ 91 ]. A hydrogel should preserve its texture, for a given time, in order to deliver a drug at a required target; this behavior can be affected by the type and concentration of the crosslinking agent.…”

Section: Sanitizing Hydrogels: Properties and Characterizationmentioning

confidence: 99%

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Hydrogels in Hand Sanitizers

Villa

Russo

2021

Materials

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Hand hygiene can be considered a strategic key useful in the containment of infections such as COVID-19 both at home and in communities because it can dramatically reduce the widespread outbreak of infections. In case of the unavailability of soap and water, “instant” hand sanitizers are recommended because their application can be considered easy, versatile, quick and often less aggressive for the skin. For these reasons, alcoholic and alcohol-free hand rub gels can be considered the best performing formulations on the market. Together with disinfectants and antiseptic agents, hydrogels play a fundamental role in obtaining stable formulations and are easy to disperse, with a pleasant skin feel and an overall good performance. Several compounds commonly used in the pharmaceutical, cosmetic and food industry are available for this purpose, in particular, cellulose derivatives and synthetic polymers derivatives. Each of them is available in several grades, presenting different thickening behavior, rheological properties and compatibility with other ingredients, alcohols in particular. For all these reasons, it is important to explore hydrogel properties and behaviors in different contexts (i.e., hydroalcoholic and aqueous media) in order to develop new and performing hand rub gels, always taking into account the different international legal frameworks regarding disinfectant and sanitizing formulations.

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Section: Sanitizing Hydrogels: Properties and Characterizationmentioning

confidence: 99%

Section: Sanitizing Hydrogels: Properties and Characterizationmentioning

confidence: 99%

Hydrogels in Hand Sanitizers

Villa

Russo

2021

Materials

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“…Among synthetic biomaterials, hydrogels consisting of natural or synthetic polymers that exhibit excellent mechanical properties and biocompatibility are ideal scaffolds to emulate extracellular matrices for cell proliferation and differentiation [ 12 , [14] , [15] , [16] , [17] ], thus leading to broad utilization in bone regeneration. Thus far, many synthetic polymers, including poly (ethylene glycol), poly (vinyl alcohol), poly (acrylic acid), and poly (lactic acid), among others, have been utilized to develop hydrogels [ [18] , [19] , [20] , [21] ]. Natural polymers such as polypeptides, polysaccharides, and polynucleotides are alternative components for hydrogel scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous incorporation of PTH(1–34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration

Zou

Wang

Zhou

et al. 2021

Bioactive Materials

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Tissue regeneration based on the utilization of artificial soft materials is considered a promising treatment for bone-related diseases. Here, we report cranial bone regeneration promoted by hydrogels that contain parathyroid hormone (PTH) peptide PTH(1–34) and nano-hydroxyapatite (nHAP). A combination of the positively charged natural polymer chitosan (CS) and negatively charged sodium alginate led to the formation of hydrogels with porous structures, as shown by scanning electron microscopy. Rheological characterizations revealed that the mechanical properties of the hydrogels were almost maintained upon the addition of nHAP and PTH(1–34). In vitro experiments showed that the hydrogel containing nHAP and PTH(1–34) exhibited strong biocompatibility and facilitated osteogenic differentiation of rat bone marrow mesenchymal stem cells (rBMSCs) via the Notch signaling pathway, as shown by the upregulated expression of osteogenic-related proteins. We found that increasing the content of PTH(1–34) in the hydrogels resulted in enhanced osteogenic differentiation of BMSCs. Implantation of the complex hydrogel into a rat cranial defect model led to efficient bone regeneration compared to the rats treated with the hydrogel alone or with nHAP, indicating the simultaneous therapeutic effect of nHAP and PTH during the treatment process. Both the in vitro and in vivo results demonstrated that simultaneously incorporating nHAP and PTH into hydrogels shows promise for bone regeneration, suggesting a new strategy for tissue engineering and regeneration in the future.

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“…The major limitations for the biomedical application of hydrogels are the non-biocompatibility of some hydrogels and potential toxicity of residual unreacted small cross-linkers in chemically crosslinked hydrogels [ 135 ]. However, among methods mentioned above, free-radical polymerization is a prevalent method used to synthesize hydrogels for biomedical applications [ 136 ].…”

Section: Tissue Engineering Of Articular Cartilagementioning

confidence: 99%

Articular and Artificial Cartilage, Characteristics, Properties and Testing Approaches—A Review

2021

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The design and manufacture of artificial tissue for knee joints have been highlighted recently among researchers which necessitates an apt approach for its assessment. Even though most re-searches have focused on specific mechanical or tribological tests, other aspects have remained underexplored. In this review, elemental keys for design and testing artificial cartilage are dis-cussed and advanced methods addressed. Articular cartilage structure, its compositions in load-bearing and tribological properties of hydrogels, mechanical properties, test approaches and wear mechanisms are discussed. Bilayer hydrogels as a niche in tissue artificialization are presented, and recent gaps are assessed.

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Acrylic acid/acrylamide based hydrogels and its properties - A review

Cited by 221 publications

References 69 publications

Hydrogels in Hand Sanitizers

Hydrogels in Hand Sanitizers

Simultaneous incorporation of PTH(1–34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration

Articular and Artificial Cartilage, Characteristics, Properties and Testing Approaches—A Review

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