Formulation Development and Characterization of Lafutidine Raft System

Abstract

Objective: The present research work is focused to develop in situ raft gel of lafutidine. Sodium alginate is one of the critical components for the development in situ raft system. Methods: The formulation was prepared using hydrophilic polymers such as ethyl cellulose, HPMC K4M, and chitosan. The formulations were subjected to evaluation characteristics such as pH, in vitro gelling time, viscosity, density, gel strength, drug-polymer compatibility studies, drug content floating lag time, swelling index, and in vitro release studies. Results: The pH of all the prepared batches was found in the range of 5.7 to 7.6. All the prepared formulations showed viscosity in the range of 264 to 320 cps, with gelling time from 4-7 s. For F1-F15 batches Floating lag time was found to be in the range of 9-24 sec. Densities of all formulations stomach specific in situ gels were in the range of 0.4 to 0.8 gm/cm3. The highest swelling index was observed in F15 with 14.16% Highest gel strength is exhibited by F15; all the formulations were in the range of 95.46–99.95, indicating the uniform distribution of the drug. Formulation F15 containing chitosan in combination with ethyl cellulose gave the highest drug release of 99.78% and also showed sustained and controlled release for up to 24h. Conclusion: F15 shows an R2 value of 0.999. As its value is nearer to the ‘1’ it is confirmed as it follows the Zero order release with an ‘n’ value is 1.5021 for the optimized formulation (F15) i.e., the n value indicates super case II transport and is considered as optimized formulation.

QUALITY BY DESIGN APPROACH FOR DEVELOPMENT AND OPTIMIZATION OF CHITOSAN-BASED FLOATING MICROSPHERES FOR TOPOTECAN HCl

“…The swelling index was determined by the soaking technique, and the results were found to be in the range of 48.5% to 156.2%. The swelling index was found to be highly variable, which may be due to the solubility of Chitosan [23] and Sodium alginate complexbased microspheres after 3 h. In a similar manner, the percent yield and swelling index were also influenced by the concentration and type of the PAC. The increment in sodium tripolyphosphate (NaTPP) and the increment in the cross-linking agent led to the decrease in swelling index [24].…”

Development and Optimization of Raft-Forming Formulation of H2blockers

“…The solutions were subjected to UV spectroscopic scanning to identify λ max of Nizatidine. The spectrum was recorded at the 200-400 nm range [7].…”

Eplerenone Floating Microspheres: Radiographic and Pharmacokinetic Studies in Rabbits

“…Microspheres have played a key role in the progress of controlled release and gastroretentive systems, as they can encapsulate miscellaneous types of drugs and small molecules, nucleic acids, and proteins [6]. They are biocompatible, can deliver superior bioavailability, and are able to release over longer periods [7]. In addition, microspheres have been technologically advanced by numerous techniques comprising combinations of phase separations or precipitations, emulsion or solvent evaporation, and spraying methods [8].…”