Formulation, Evaluation and Antioxidant activity of Caffeine Fast Melt Tablets

El-Nabarawi, Mohamed A.; Teaima, Mahmoud H.; Hamid, Magdi M. Abdel; Shoman, Nabil A; Mohamed, Amir Ibrahim; El-Sahar, Ayman E.

doi:10.5958/0974-360x.2018.00575.9

Cited by 7 publications

(7 citation statements)

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“…These results were attributed to the complicated matrix of Prosolv ODT, which contained mannitol and fructose and crospovidone and MCC, thus increasing its matrix's strength and increased its WT. This result agrees with El-Nabarawi et al 43 where the Prosolv ODT-based formula showed relatively longer WT than other formulae although crospovidone's presence. Also, Sunada and Bi studied the WT of tablets containing MCC, and they found that tablets containing MCC showed lower porosity (lower water uptake) than other formulae and longer WT.…”

Section: Wetting Timesupporting

confidence: 91%

Formulation and Evaluation of Baclofen-Meloxicam Orally Disintegrating Tablets (ODTs) Using Co-Processed Excipients and Improvement of ODTs Performance Using Six Sigma Method

Abdelmonem¹,

Abdellatif²,

Al-Samadi³

et al. 2021

DDDT

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Purpose: This study aimed to formulate an orally disintegrating tablet (ODT) containing both baclofen and meloxicam together for treating osteoarthritis. Methods: Direct compression method was used to prepare ODTs using three types of coprocessed excipients (Prosolv ODT G2 ® , F-melt ® , and Pharmaburst ® 500). ODTs were evaluated according to weight variation, thickness, friability, hardness, drug content, wetting time, in-vitro disintegration time, in-vitro dissolution test, and palatability. To enhance the in-vitro dissolution of meloxicam and palatability of ODT, a six sigma methodology was used, and an improvement phase was established where ODTs were prepared using lyophilization and levigation techniques. Finally, a pharmacokinetic study of the improved ODT was accomplished in comparison to the conventional oral tablet. Results: Pharmaburst-based formula (F4) showed the shortest wetting time and, consequently, the shortest disintegration time and the highest percentage of drug dissolved within 3 min compared to the other formulae. All the improved ODTs had a bitterness taste score vary from (0) palatable and (+1) tasteless. The current sigma level was 3.628 σ and 3.33 σ for palatability and solubility of ODT, respectively, which indicated the process was successfully improved compared with the previous sigma level of 2.342 σ of both processes. Pharmacokinetic study of the improved ODTs showed a significant decrease of T max to 120 and 30 min instead of 180 and 120 min for meloxicam and baclofen, respectively. Conclusion: ODTs were successfully improved using the six sigma methodology, the pharmacokinetic parameters of both drugs were enhanced due to rapid absorption through the oral mucosa.

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Section: Wetting Timesupporting

confidence: 91%

Formulation and Evaluation of Baclofen-Meloxicam Orally Disintegrating Tablets (ODTs) Using Co-Processed Excipients and Improvement of ODTs Performance Using Six Sigma Method

Abdelmonem¹,

Abdellatif²,

Al-Samadi³

et al. 2021

DDDT

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“…The strength of a tablet plays a very important role in its marketing and dissolution. The generally agreed upper limit for friability is 1% [20]. All ODTs did not break or show any capping, cracking, or chipping during the test.…”

Section: Characterization Of the Prepared Formulaementioning

confidence: 78%

“…In vitro dissolution tests were performed with a dissolution tester, set with a paddle speed of 50 rpm, using 300 ml of distilled water at 37±0.5 °C as a dissolution medium. At specified time intervals (5,10,15,20,30,45,60 min) aliquots of 3 ml of dissolution media were withdrawn and replaced with an equal volume of the fresh medium drug content was assayed spectrophotometrically at 214 nm. Drug concentration was expressed as the cumulative percent drug dissolved.…”

Section: In Vitro Dissolutionmentioning

confidence: 99%

Formulation and Characterization of Odt Using Different Co-Process Containing Daclatsvir: In Vitro and in Vivo Pharmacokinetics Study on Healthy Volunteers for Hepatitis C Treatment

Abouhussein

Teaima²,

Al-Nuseirat³

et al. 2022

Int J App Pharm

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Objective: This study aimed to prepare and evaluate oral disintegrating tablets (ODTs) of Daclatasvir dihydrochloride (DCV) using different co-processed excipients to enhance drug dissolution and improve oral bioavailability for the treatment of hepatitis C infection. Methods: Ten Daclatasvir-ODTs formulae were prepared using co-processed excipients via direct compression. The prepared formulae were evaluated according to taste masking, weight variation, thickness, friability, hardness, drug content, and wetting time. In vitro disintegration time, in vivo disintegration time, and in vitro dissolution tests were also evaluated and taken as parameters for the selection of the best formula. The selected best formula was subjected to an in vivo study on volunteers and compared to a marketed product. Results: All DCV-ODTs had acceptable physical properties in accordance with pharmacopeial standards. DCV-ODTs prepared with Pharmaburst® (F10) recorded the shortest wetting time (14±0.08s), fastest in vitro disintegration time (46±0.16s), shortest in vivo disintegration time (27±0.16s), and attained the fastest onset of dissolution (94.3±0.03 %) at 5 min to all other excipients and has been identified as the best formula. The in vivo pharmacokinetic study showed that the Pharmaburst-based formula has a significant Cmax increase of (2.17±0.28 μg/ml) compared to (1.42±0.59) for the marketed product and a significant decrease of Tmax to 60 min instead of 110 min for the marketed product. Conclusion: The in vivo pharmacokinetic study in humans showed that the ODTs was found to be appropriate for delivery of Daclatasvir with a faster drug absorption rate when compared to the marketed products with applicable taste related to the nature of dosage form.

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“…Wetting time has a significant impact on tablet disintegration time. The tablet's wettability can considerably reduce disintegration time [11]. F4 and F5 showed a comparable wetting time of (32.45 and 32.86s) respectively; this is related to the presence of crospovidone and mannitol.…”

Section: Wetting Timementioning

confidence: 88%

“…The solution was filtered; 1 ml of filtrate was taken into 100 ml of the volumetric flask, diluted with SSF (pH 6.8), and measured the absorbance at the predetermined λmax (205 nm) through a preconstructed standard calibration curve using a UV-VIS spectrophotometer. Measurements were performed in triplicate for each formula, and the results were represented as mean±SD [11].…”

Section: Uniformity Of Drug Content Testmentioning

confidence: 99%

The Effect of Co-Processed Excipients During Formulation and Evaluation of Pediaric Levetiracetam Orodispersible Tablets in Rats

Teaima

MESSIRY²,

OSMAN³

et al. 2023

Int J App Pharm

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Objective: The main aim of this research was to make cost-effective taste-masking oral pediatric orodispersible tablets (ODTs) of Levetiracetam as an antiepileptic drug (AED) using various co-processed excipients by direct compression method. Methods: Eight kinds of ready-made co-processed excipients in addition to sucralose and menthol as a sweetener, were utilized. The weight variation, drug content, friability, in vitro disintegration, dissolution time, hardness, thickness, and pharmacokinetics of the produced ODTs were determined. Results: The optimized formula (F5) containing Pharmaburst® 500 showed the shortest disintegration time (11.66 sec) and more than 98% of Levetiracetam within 10 min (Q10). The Pharmacokinetic study of this optimum formula (F5) in rats using an HPLC-UV detector showed 26.904±2.027 ng/ml as the Cmax and 101.935±0.894 h ng/ml as AUC compared to commercial Tiratam® solution 10.421±0.295ng/ml and 23.135±0.43 h ng/ml respectively. Conclusion: Levetiracetam orally orodispersible tablets were successfully prepared with acceptable hardness, satisfactory taste, and rapid disintegration in the oral cavity avoiding first-pass metabolism to yield the desired rapid effect in facing epilepsy for patients who experience dysphagia like pediatric and geriatric. In addition to the unconsciousness of the epileptic patient followed the seizure attack.

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Formulation, Evaluation and Antioxidant activity of Caffeine Fast Melt Tablets

Cited by 7 publications

References 0 publications

Formulation and Evaluation of Baclofen-Meloxicam Orally Disintegrating Tablets (ODTs) Using Co-Processed Excipients and Improvement of ODTs Performance Using Six Sigma Method

Formulation and Evaluation of Baclofen-Meloxicam Orally Disintegrating Tablets (ODTs) Using Co-Processed Excipients and Improvement of ODTs Performance Using Six Sigma Method

Formulation and Characterization of Odt Using Different Co-Process Containing Daclatsvir: In Vitro and in Vivo Pharmacokinetics Study on Healthy Volunteers for Hepatitis C Treatment

The Effect of Co-Processed Excipients During Formulation and Evaluation of Pediaric Levetiracetam Orodispersible Tablets in Rats

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