Formulation, in Vitro and Ex Vivo Characterization of Mucoadhesive Buccal Tablets for Antihypertensive Drug

Peddapalli, Himabindu; Bakshi, Vasudha; Boggula, Narender

doi:10.22159/ajpcr.2018.v11i8.26126

Cited by 15 publications

(9 citation statements)

References 13 publications

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“…The surface pH of the tablets was in the range of 6.72–6.96, which was almost similar to the pH of the buccal cavity. Therefore, all the batches do not produce mucosal irritation and discomfort and improve patient compliance [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Formulation and evaluation of mucoadhesive buccal tablets of aceclofenac

Koirala

Nepal

Ghimire

et al. 2021

Heliyon

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This project was aimed to formulate and characterize mucoadhesive buccal tablets of aceclofenac, utilizing different proportions of three polymers carbopol 934, hydroxypropyl methylcellulose, and sodium carboxymethylcellulose. Twelve batches of buccoadhesive aceclofenac were prepared by the direct compression method. The compressed tablets were then evaluated for physicochemical parameters such as hardness, thickness, weight variation, drug content, friability, swelling index, surface pH, and ex vivo mucoadhesion. In vitro dissolution test was conducted for 12 h according to Indian Pharmacopeia 2018, using the rotating paddle method in phosphate buffer of pH 7.4. Physiochemical parameters like weight variation (231.25–268.75 mg), hardness (8.32–11.56 kg), friability (0.04–0.2%), diameter (9.00 mm), thickness (3.8–4.05 mm), and drug content ((97.67–102.25%) were within the acceptable limit as per Indian Pharmacopeia 2018. The swelling index was reported to be in the range of 112.93–450.19%, at 8 h. The surface pHs of all the batches were in between 6.72 to 6.96. The mucoadhesive strengths (40.5–50 g) varied with the change in polymer concentrations especially of carbopol 934. The dissolution profile of all the batches varied greatly, with a maximum release of 109.41% (in batch 12 at 6 h) to a minimum release of 44.82% (in batch 3 at 12 h). Among them, only batch 1 ensured sustained and effective drug release (88.34% at 12 h) with appropriate swelling index (112.93%) and mucoadhesive strength (40 g). Fourier Transform Infrared Spectroscopy analysis showed no evidence of drug excipients interaction. Hence, the results concluded that buccal mucoadhesive aceclofenac tablets can be formulated. Furthermore, the property of the tablet not only depends on the concentration but also the behavior of the polymers used.

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Section: Discussionmentioning

confidence: 99%

Formulation and evaluation of mucoadhesive buccal tablets of aceclofenac

Koirala

Nepal

Ghimire

et al. 2021

Heliyon

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“…The inner core tablets were prepared by using the direct compression method [15] as shown in the table. Powder mixtures zafirlukast, Plantago ovata seed powder, Locust bean gum, Sodium starch glycolate, Crospovidone, CCS, talc ingredients were blended for 20 min followed by the addition of Magnesium stearate.…”

Section: Formulation Development Of Tabletsmentioning

confidence: 99%

Formulation Development and Evaluation of Chronomodulated Drug Delivery System by Zafirlukast

Krishna¹,

Jayanthi²,

Madhukar³

2021

Int J App Pharm

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Objective: The main objective of the present study was to formulate and evaluate a time-controlled single-unit oral pulsatile drug delivery system containing Zafirlukast for the prevention of nocturnal asthma attacks. To provide time-scheduled drug release for Asthma disease. It is used for preventing asthmatic attacks at early morning. Pulsatile release dosage form is increasing patient compliance by reducing the dosing frequency, especially in the early morning. Methods: Core tablets were prepared by incorporating different concentrations of natural and synthetic super disintegrants. Drug-containing core tablets (ZC1-ZC15) with different compositions of natural super disintegrants (Plantago ovata seed powder, Locust bean gum) synthetic super disintegrants (Sodium starch glycolate (SSG), Cross carmellose sodium (CCS), Crospovidone (CP)) were prepared by direct compression technique. The core tablets were subjected to pre-formulation, physicochemical and In vitro drug release studies. The fast disintegrating core tablet formulation was selected and press-coated tablets (P1-P11) were prepared with different compositions of hydrophobic polymers Eudragit RS100, Eudragit RL 100, Ethylcellulose and hydrophilic polymers Hydroxypropyl methylcellulose K4M, K100M. The optimized formulation was selected and quantified based on in vitro drug release profile in simulated gastric and intestinal fluids. Results: The pre and post-compression parameters of tablets were also found to be within limits. Formulation ZC5 with 16 mg of Locust bean gum showed the least disintegrating time, i.e., 22.13 sec, and was selected as the best immediate release core tablet. The press-coated tablet formulation P8 having 62.5 mg Eudragit RS100 and 62.5 mg of HPMC K4M in ratio 1:1 over the core tablet ZC5 showed rapid and drug release nearly after 4 h lag time and 98.86 % up to 12 h. Accelerated stability studies of the optimized formulation P8 indicated no significant difference in release profile after 3 mo. Conclusion: The in vitro dissolution study showed that lag time before drug release was highly affected by the coating amount level and nature of coating polymer used. Time-controlled pulsatile release tablets can be prepared using press-coating techniques.

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“…The solubility of Glipizide , (Banker and Rhodes, 2002;Peddapalli et al, 2018),was studied in 0.1N HCL (pH 1.2) solution by phase equilibrium method. In a 20 ml vial, 10 mL above resolution, an excessive amount of drug was taken.…”

Section: Solubility Studiesmentioning

confidence: 99%

Formulation and Evaluation of Floating and Mucoadhesive tablets containing Glipizide

Arun

Pattanayak

Shrivastava

et al. 2020

ijrps

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In the present study, Glipizide, a drug mainly preferred for type-II diabetes, is formulated in the form of floating mucoadhesive tablets to improve its bioavailability. Hydroxy Propyl Methyl Cellulose K200M, Sodium Carboxy Methyl Cellulose, Carbopol 974P, Karaya gum, Chitosan, and Xanthan gum were used as mucoadhesive polymers in designing of the floating mucoadhesive tablets. Different proportions of glipizide and polymer were used to prepare tablets. Pre-compression evaluation studies evaluated the powder blend of Glipizide mucoadhesive tablets (Pre-compression blend). It concluded that the blend had good flow property and better compressibility by interpreting the data obtained from the test. Hence the floating mucoadhesive tablets were prepared by direct compression technique. The results of floating lag time, and buoyancy studies suggested that formulations had a satisfactory floating ability. The release profile of the active pharmaceutical ingredient (glipizide) from the prepared dosage form indicated a controlled and enhanced drug release for a period of 12hrs. An in-vivo study done for selected formulation. By the interpretation of data obtained from all the evaluation studies (Pre-compression test, floating property, drug release profile, & in-vivo study) concluded that formulation GF8 containing drug: Carbopol 974P (1:2) was optimized. The drug release kinetics of the formulation GF8 followed the Higuchi model with a regression value of 0.993.

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Formulation, in Vitro and Ex Vivo Characterization of Mucoadhesive Buccal Tablets for Antihypertensive Drug

Cited by 15 publications

References 13 publications

Formulation and evaluation of mucoadhesive buccal tablets of aceclofenac

Formulation and evaluation of mucoadhesive buccal tablets of aceclofenac

Formulation Development and Evaluation of Chronomodulated Drug Delivery System by Zafirlukast

Formulation and Evaluation of Floating and Mucoadhesive tablets containing Glipizide

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