Formulation of Controlled Release Gellan Gum Macro Beads of Amoxicillin

Abstract

Gellan gum has been reported to have wide pharmaceutical applications such as tablet binder, disintegrant, gelling agent and as a controlled release polymer. Multiparticulate delivery systems spread out more uniformly in the gastrointestinal tract and reduce the local irritation. The purpose of this study is to explore possible applicability of gellan macro beads as an oral controlled release system of a sparingly soluble drug, amoxicillin. Gellan gum beads were prepared by ionotropic gelation with calcium ions. The effect of drug loading, stirring time, polymer concentration, electrolyte (CaCl2) concentration, curing time etc. influencing the preparation of the gellan gum macro beads and the drug release from gellan gum beads were investigated in this study. Optimal preparation conditions allowed very high incorporation efficiency for amoxicillin (91%) The release kinetics of amoxicillin from gellan beads followed the diffusion model for an inert porous matrix in the order: 0.1 N HCl > phosphate buffer > distilled water. Change in curing time did not significantly affect the release rate constant, but drug concentration, polymer concentration and electrolyte concentration significantly affect the release rate of amoxicillin from the beads. The gellan macro beads may be suitable for gastro retentive controlled delivery of amoxicillin.

Al+3 ion cross-linked and acetalated gellan hydrogel network beads for prolonged release of glipizide

“…They showed that an increase in AlCl 3 con- centration from 20% to 60% (w/v) decreased the mean diameter of diclofenac sodium-loaded aluminum carboxymethyl cellulose beads from 2.30 mm to 1.80 mm. Babu et al (2010) found that the mean diameter of gellan beads decreased (2.80-2.40 mm) with increasing concentration of calcium chloride (0.1-0.4 M).…”

“…Due to its ability to form hydrogel beads in presence of divalent cations, particularly Ca +2 ions, gellan gum has been investigated for the controlled release of various kinds of drugs (Agnihotri, Jawalkar, & Aminabhavi, 2006;Babu, Sathigari, Kumar, & Pandit, 2010;Kedzierewicz, Lombry, Rios, Hoffman, & Maincent, 1999;Patil, Sharma, Nimbalkar, & Pawar, 2006;Rajinikanth & Mishra, 2007). Most of the in vitro drug release studies have been conducted either in acidic or alkaline dissolution media.…”

Floating-bioadhesive gastroretentiveCaesalpinia pulcherrima-based beads of amoxicillin trihydrate forHelicobacter pylorieradication

“…Amoxicillin is the model drug for the treatment against H. pylori. As it is acid-soluble in nature, it is very difficult to control its drug release for an extended period in the gastric environment of stomach (Liu et al, 2004;Babu et al, 2010;Arora et al, 2011).…”

Formulation and In Vitro evaluation of pH sensitive oil entrapped buoyant beads of amoxicillin.

“…Narkar et al [8] prepared and evaluated the oral mucoadhesive beads of amoxicillin. Babu et al [9] prepared gellan gum macro beads of amoxicillin. The oil entrapped pectin gel beads were found to be a potential candidate for targeted drug delivery and are anticipated to be useful in the treatment of microbial infection in the gastric region [10].…”