2017
DOI: 10.29208/jsfk.2017.4.1.201
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Formulation of Metformin HCl Floating Tablet using HPC, HPMC K100M, and the Combinations

Abstract: Diabetes Floating tablet is one of the most suitable dosage forms that used for delivering long term drug release. The objective of this study was to evaluate Hydroxypropyl cellulose (HPC), Hydroxypropyl Methyl Cellulose (HPMC) K100M, and the combination as matrix in manufacturing floating tablets. Metformin HCl, an anti-diabetic, was used as a drug model. Metformin HCl floating tablet was manufactured by wet granulation method in three formulas using variation of matrix, which were 40% of HPC (F1), 40% of HPM… Show more

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