Formulation of Sustained Release Chlorpheniramine maleate Matrix Tablets through Optimization and their Evaluation.

Abstract

The object of the present study is to develop sustained release system of the antihistaminic agent chlorpheniramine maleate generally used in allergic disorders common cold and other conditions. Matrix tablet is one of the least complicated devices to sustain the release of drug candidates. Different grades of polymers HPMC viz HPMCK4M and HPMCK15M were selected to sustain the release up to 12 hrs. Optimization techniques using factorial design for two factors at three levels (3 2 ) was selected to optimize varied response variables viz. release rate exponent (n), t50%, k, amount of drug released in 12h (Rel12h) and mean dissolution time MDT. The optimum formulations were selected and the results obtained with the experimental values were compared with the predicted values. In conclusion, the results suggest that the developed sustained-release matrix tablets could provide quite regulated release of chlorpheniramine maleate up to nearly 12 hr.

Optimized chronomodulated dual release bilayer tablets of fexofenadine and montelukast: quality by design, development, and in vitro evaluation

“…The goodness of fit of the proposed model for disintegration time was investigated by plotting diagnostic plots ( Fig. 6a-d) [30]. The normal probability plot of externally studentized residuals indicated that most of the colored points depicting values of disintegration time were located around the normal probability line, which proved the normality of residuals and suggested the relevant analysis of response data.…”

“…The goodness of fit of the proposed model for drug release from sustained release tablet layer was investigated by plotting diagnostic plots ( Fig. 6i-l) [30]. The normal probability plot of externally studentized residuals indicated that most of the colored points depicting values of the percentage of drug release were located around the normal probability line.…”