Formulation of the novel structure curcumin derivative–loaded solid lipid nanoparticles: synthesis, optimization, characterization and anti-tumor activity screening <i>in vitro</i>

Li, Ké; Pi, Chao; Wen, Jie; He, Yingmeng; Yuan, Jiyuan; Shen, Hongping; Zhao, Wenmei; Zeng, Mingtang; Song, Xinjie; Lee, Robert J.; Wei, Yumeng; Zhao, Ling

doi:10.1080/10717544.2022.2092235

Cited by 14 publications

(8 citation statements)

References 41 publications

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“…In recent years, the antitumor effect of CUR has attracted attention. Some studies have found that CUR can prevent tumor angiogenesis and cell proliferation, induce cancer cell apoptosis, downregulate epidermal growth factor receptor (EGFR) activity and human epidermal growth factor receptor 2 (HER2) expression levels, downregulate nuclear transcription factor, inhibit the activation of the STAT3 signaling pathway, downregulate the expression level of cyclooxygenase 2 (COX-2), and reduce the synthesis level of MMP9 and inducible nitric oxide synthase (iNOS), thus exerting its antitumor effect through multiple pathways [ 14 , 15 ]. However, the application of CUR is constrained by its low water solubility, ease of aqueous solution hydrolysis, clear first-pass elimination effect and low bioavailability [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…Tumor therapy that targets the Hippo-YAP signaling pathway has gained popularity in recent years. YAP-like peptides created by Zhou et al [ 14 ] have demonstrated their ability to inhibit tumor growth in primary liver cancer xenograft models. Our study indicates that WZ10 may decrease tumor activity in vitro through the Hippo-YAP pathway, induce cell apoptosis and limit cell proliferation and invasion, supporting WZ10 as a promising medication for the therapeutic treatment of ovarian cancer patients.…”

Section: Discussionmentioning

confidence: 99%

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Molecular Mechanism of Curcumin Derivative on YAP Pathway against Ovarian Cancer

Nan

Liu

Zeng

et al. 2022

JCM

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The purpose of this study is to study the effect of curcumin derivative WZ10 on the proliferation, invasion and apoptosis of ovarian cancer OVCAR3 cells, and to explore its mechanism. MTT assay was used to detect the effect of WZ10 on the proliferation of ovarian cancer OVCAR3 cells; Annexin V/PI double staining flow cytometry was used to detect the effect of WZ10 on cell apoptosis; Transwell method was used to detect the effect of WZ10 on cell invasiveness; Western blot was used to investigate the effect of WZ10 Mechanisms affecting OVCAR3 activity in ovarian cancer in vitro. Our results show that WZ10 treatment could significantly inhibit the proliferation and invasion of OVCAR3 cells, induce apoptosis of OVCAR3 cells in a dose-dependent manner. After knockdown of Hippo expression with sh-RNA, further combined treatment with WZ10 had no significant image on ovarian cancer OVCAR3 cells. In conclusion: WZ10 can significantly inhibit the proliferation of OVCAR3 cells, reduce cell invasion and proliferation by downregulating the activation of Hippo-YAP pathway, and induce cell apoptosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Molecular Mechanism of Curcumin Derivative on YAP Pathway against Ovarian Cancer

Nan

Liu

Zeng

et al. 2022

JCM

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“…The encapsulation efficiency was calculated as the difference between the added content of coumarin-6 and the content in the supernatant. 15 …”

Section: Methodsmentioning

confidence: 99%

“…The encapsulation efficiency was calculated as the difference between the added content of coumarin-6 and the content in the supernatant. 15 Coumarin 6 release from DFPs was determined by suspending DFPs in Hank's balanced salt solution (HBSS, 2.0 mL) at pH 7.2. The suspension was placed in a dialysis bag (molecular weight cutoff=5000 Da), followed by immersion in another 20.0 mL HBSS at 37°C with agitation at a constant speed of 100 r/min.…”

Section: Preparation and Characterization Of Dfpsmentioning

confidence: 99%

Customizable Dual-Fluorescent Nanoparticles for Tracing and Quantifying of Cell Transport

Ta¹,

Li²,

Song³

et al. 2023

IJN

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Nanotechnology-based drug delivery systems (nano-DDS) have been developed to be a promising strategy to improve the efficacy, safety, physicochemical and pharmacokinetic/pharmacodynamics properties of drugs. It is very necessary to elucidate the delivery process in vivo or in cells for the rational design and accurate preparation of nano-DDS. The aim of this study was to construct a nano-DDS to visualize and quantify the intracellular behavior of the loaded cargo and carrier in such a system. Methods: A carboxyl-terminal end of poly(lactic-co-glycolic acid) polymer was fluorescently labeled with rhodamine B by conjugation of ethylenediamine. Dual-fluorescent nanoparticles (DFPs) were prepared from this fluorescently labeled polymer to encapsulate a fluorescent cargo, coumarin 6. The carrier and cargo of DFPs were monitored by confocal fluorescence microscopy during cellular uptake. Furthermore, the transcellular transportation of DFPs was evaluated quantitatively by measuring the fluorescence intensity. Results: The obtained fluorescent polymer showed stable and quantifiable characteristics. DFPs could be customized in terms of coumarin 6 content (97.7±1.0%), size (367.3±1.7 nm) and dual-emission fluorescence (green cargo and red carrier). DFPs did not significantly affect cell viability, the integrity of cell monolayers and the microscopic morphology at concentrations below 0.7 mg/mL within 3 h of co-incubation with Caco-2 cells. Multichannel fluorescence monitoring revealed that the fluorescence intensity of the carrier and cargo increased with time, but not synchronously. By calculating the residual, intracellular, and transport amounts of DFPs, the material balance between the total amount of cellular transport and the dose administered was obtained. Conclusion:Based on the advantages of dual fluorescent labeling, the differential behavior of cell trafficking can be visualized and quantitatively analyzed for the cargo and carrier of DFPs. These results provide insights into the cellular transport process of holistic nanoparticles and complement our understanding of the biological behaviors of nano-DDS.

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“…Results showed improved bioavailability and inhibitory effects as compared to CU. [ 156 ] Furthermore, a combinational strategy was employed to utilize a multi‐drug‐loaded SLN with PTX and CU in a lung cancer xenograft tumor model, and the findings revealed high clinical therapeutic potential for lung cancer therapies. [ 157 ] However, these studies utilized NPs to be passively targeted.…”

Section: Smart Lipid‐based Nanocarriersmentioning

confidence: 99%

Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions

Shahrivar,

Fakhr,

Abbasgholinejad

et al. 2023

Advanced Therapeutics

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Lung cancer remains the leading cause of cancer‐related deaths worldwide, and conventional treatments for the disease often fall short. Smart nanoparticles (NPs) are emerging as a promising strategy for the treatment of lung cancer, owing to their ability to selectively deliver therapeutic agents to cancer cells while minimizing off‐target effects. Smart NPs can respond to specific stimuli such as changes in pH, temperature, or enzymes, allowing them to release their cargo only when triggered. Among the various types of smart NPs, lipid‐based NPs, including liposomes, solid lipid nanoparticles, cubosomes, and extracellular vesicles, have garnered the highest interest due to their biocompatibility, low toxicity, and versatility in encapsulating a wide variety of drugs and genetic material. This review discusses the current status of smart lipid‐based NPs in lung cancer treatment, including recent advances in targeting strategies, stimuli‐responsive NPs, and combination therapies. The challenges and opportunities associated with translating smart lipid‐based NPs for lung cancer treatment into clinical applications are also discussed. This review highlights the potential of smart lipid‐based NPs to revolutionize lung cancer treatment and improve patient outcomes.

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Formulation of the novel structure curcumin derivative–loaded solid lipid nanoparticles: synthesis, optimization, characterization and anti-tumor activity screening in vitro

Cited by 14 publications

References 41 publications

Molecular Mechanism of Curcumin Derivative on YAP Pathway against Ovarian Cancer

Molecular Mechanism of Curcumin Derivative on YAP Pathway against Ovarian Cancer

Customizable Dual-Fluorescent Nanoparticles for Tracing and Quantifying of Cell Transport

Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions

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