Formulation of transdermal patch of Losartan Potassium &amp; Glipizide for the treatment of hypertension &amp; diabetes

Bhairam, Monika; Prasad, Jhakeshwar; Verma, Khushboo; Jain, Parag; Gidwani, Beena

doi:10.1016/j.matpr.2023.01.147

Cited by 9 publications

(1 citation statement)

References 3 publications

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“…As known, the transdermal administration of a drug to achieve systemic effects offers several significant advantages and often surpasses oral or intravenous drug delivery in many situations. Among the numerous benefits of transdermal drug delivery, particular attention is drawn to the ability to bypass first-pass metabolism in the liver and eliminate unwanted effects on the gastrointestinal tract [9][10][11][12][13]. Additionally, it prevents potential degradation of the active substance in the digestive system and avoids the possibility of drug interactions with food and other orally administered medications.…”

Section: Introductionmentioning

confidence: 99%

Enhancing Transdermal Delivery: Investigating the Impact of Permeation Promoters on Ibuprofen Release and Penetration from Medical Patches—In Vitro Research

Bednarczyk,

Nowak,

Duchnik

et al. 2023

IJMS

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This study investigated the impact of various enhancers on permeation through the skin and accumulation in the skin from acrylic pressure-sensitive adhesive-based drug-in-adhesives matrix-type transdermal patches. Eleven patches, each containing a 5% enhancer of permeation, encompassing compounds such as salicylic acid, menthol, urea, glycolic acid, allantoin, oleic acid, Tween 80, linolenic acid, camphor, N-dodecylcaprolactam, and glycerin, were developed. Ibuprofen (IBU) was the model active substance, a widely-used non-steroidal anti-inflammatory drug. The results were compared to patches without enhancers and commercial preparations. The study aimed to assess the effect of enhancers on IBU permeability. The adhesive properties of the patches were characterised, and active substance permeability was tested. The findings revealed that patches with 5% allantoin exhibited the highest IBU permeability, approximately 2.8 times greater than patches without enhancers after 24 h. These patches present a potential alternative to commercial preparations, highlighting the significant impact of enhancers on transdermal drug delivery efficiency.

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Section: Introductionmentioning

confidence: 99%

Enhancing Transdermal Delivery: Investigating the Impact of Permeation Promoters on Ibuprofen Release and Penetration from Medical Patches—In Vitro Research

Bednarczyk,

Nowak,

Duchnik

et al. 2023

IJMS

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Nano-biomaterials: A Site-Targeted Approach to Antidiabetic Drug Delivery

Bhairam,

Dubey,

Pandey

et al. 2024

Biomaterial-Inspired Nanomedicines for Targeted Therapies

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Study of thermally induced interactions between active substances from the sartans class and various excipients

Cernușcă,

Bradu,

Pahomi

et al. 2024

J Therm Anal Calorim

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Sartans, also known as angiotensin receptor blockers, comprise a category of antihypertensive medications designed to inhibit the actions of angiotensin II (Ang II) in the body, ultimately reducing blood pressure levels. This class of compounds is derived from 2-(1-benzyl-1H-imidazol-5-yl)-acetic acid, with its origin characterized by an imidazole core that underwent various substitutions at specific positions within the heterocyclic nucleus. We investigated the behavior of Losartan, Valsartan and Irbesartan and their compatibility with various excipients used in pharmaceutical tablet formulations by FTIR spectroscopic studies, thermal behavior by thermogravimetry and differential scanning calorimetry. The aim of the study was to determine the excipients to be used in pharmaceutical formulations containing drugs from the class of sartans as active ingredients. Our study concludes by recommending precautionary measures in elaborating new solid formulations containing lactose in the case of Losartan.

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Formulation of transdermal patch of Losartan Potassium & Glipizide for the treatment of hypertension & diabetes

Cited by 9 publications

References 3 publications

Enhancing Transdermal Delivery: Investigating the Impact of Permeation Promoters on Ibuprofen Release and Penetration from Medical Patches—In Vitro Research

Enhancing Transdermal Delivery: Investigating the Impact of Permeation Promoters on Ibuprofen Release and Penetration from Medical Patches—In Vitro Research

Nano-biomaterials: A Site-Targeted Approach to Antidiabetic Drug Delivery

Study of thermally induced interactions between active substances from the sartans class and various excipients

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