Formulation strategies to provide oxygen-release to contrast local hypoxia for transplanted islets

Wang, Zeqing; Jiang, Zhikai; Lu, Ruijie; Kou, Longfa; Zhao, Ying‐Zheng; Yao, Qing

doi:10.1016/j.ejpb.2023.04.015

Cited by 5 publications

(2 citation statements)

References 78 publications

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“…10 Thus, the lack of the vasculature network leads to inadequate oxygen and nutrient supply to the islets and profoundly affects the islets’ survival and function. 11,12 Sufficient oxygen supply is a must to ensure a functional islet graft, especially during the early stages of transplantation. However, while tissue hypoxia typically promotes local angiogenesis, 13 it proves to be fatal for islets.…”

Section: Introductionmentioning

confidence: 99%

“…, oxygen delivery using gas carriers, oxygen-producing biomaterials, and photosynthetic biomaterials to the transplantation site. 20 The external oxygen delivery method has been proven to be effective at improving the islet viability and function in animal models. But its application faces many obstacles, like the stability and safety of delivery carriers and the regulation of oxygen delivery efficiency and direction.…”

Section: Introductionmentioning

confidence: 99%

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Biomaterial-assisted strategies to improve islet graft revascularization and transplant outcomes

Qi,

Ding,

Zhang

et al. 2024

Biomater. Sci.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biomaterial-assisted strategies to improve islet graft revascularization and transplant outcomes

Qi,

Ding,

Zhang

et al. 2024

Biomater. Sci.

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A Bioartificial Pancreas with “Immune Stealth” and Continuous Oxygen Supply for Islet Transplantation

Zheng,

Yang,

Gao

et al. 2023

Macromol. Rapid Commun.

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Transplantation of microencapsulated islet cells remains a promising strategy for the normalization of glucose metabolism control in type 1 diabetes mellitus. However, vigorous host immunologic rejection, fibrotic overgrowth around the microcapsules and poor oxygen supply often lead to graft failure. Herein, a bioartificial pancreas is constructed that incorporates the “stealth effect” based on polyethylene glycol copolymers and the high oxygen‐carrying performance of fluorinated nanoparticles. Polycationic poly(L‐lysine)‐grafted‐poly(ethylene glycol) is successfully coated on the surface of alginate microcapsules through electrostatic interaction, which can not only resist fibrinogen adhesion and avoid excessive fibrosis around the microcapsules, but also isolate the host immune system from attacking, achieving a “stealth effect” of microencapsulated islet cells. Furthermore, the co‐loading of fluoride‐based O2 nanocarriers gives them enhanced oxygen‐carrying and continuous oxygen supply capabilities, thereby effectively prolonging the survival of islet cells. The intracapsular islet cells still display similar cell viability and almost normal insulin secretion function even in long‐term culture under hypoxic conditions. Collectively, this work opens up a new approach for microencapsulated islets to efficiently evade host immune attack and improve oxygen supply, and provides a promising strategy for islet transplantation in type 1 diabetes mellitus.This article is protected by copyright. All rights reserved

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A novel intravascular bioartificial pancreas device shows safety and islet functionality over 30 days in nondiabetic swine

Photiadis,

Mai,

Montanez

et al. 2024

American Journal of Transplantation

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Formulation strategies to provide oxygen-release to contrast local hypoxia for transplanted islets

Cited by 5 publications

References 78 publications

Biomaterial-assisted strategies to improve islet graft revascularization and transplant outcomes

Biomaterial-assisted strategies to improve islet graft revascularization and transplant outcomes

A Bioartificial Pancreas with “Immune Stealth” and Continuous Oxygen Supply for Islet Transplantation

A novel intravascular bioartificial pancreas device shows safety and islet functionality over 30 days in nondiabetic swine

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