The consumption of natural products
against gastrointestinal
disorders
has been increasing. Although there are pharmaceutical treatments,
they present side effects, so new alternatives like nutraceuticals
are investigated. Salvilla is used as a traditional treatment due
to its bioactive phenolic content. Such extracts may be obtained by
ultrasound assisted extraction (UAE) and microencapsulated to preserve
them and develop a nutraceutical product. Therefore, salvilla extract
was obtained by UAE and microencapsulation by spray drying (SD). Treatments
were tested for yield, moisture, antioxidant activity, quantification
of phenolic compounds, flow analysis, spectrometry by Raman and FTIR-ATR,
extract release, and COX-2 inhibition. All treatments presented high
antioxidant activity (74.8–93.4%). UPLC analysis showed a higher
concentration of flavonoids than phenolic acids. Microencapsulation
was confirmed, showing an inhibition of 55% of COX-2. Treatment SD8/160
showed a good protection of compounds and COX-2 inhibition. Thus,
SD technology is a good option in the formulation of salvilla nutraceuticals.