Formyleleganolone and bibifuran, two metabolites from the brown alga Bifurcaria bifurcata

Marine natural products

“…Two studies on Bifucaria bifurcata (Roscoff, France) dened the metabolic makeup of this alga with the isolation of the sesquiterpenoids formyleleganolone 463, bibifuran 464 and four new eleganolone derivatives 465-468. 481,482 Also isolated were eleganolone, 483 ve previously described eleganolone derivatives [484][485][486][487][488] and 16-hydroxygeranylgeraniol 489 (isolated for the rst time from this species) which collectively can be correlated in a hypothetical metabolic grid. 482 In a follow-up study the structures and relative congurations of a further 13 dolabellane diterpenoids 469-481 from the alga Dilophus spiralis (Elafonissos Is., Greece) were described along with the antibacterial properties of 469-477 and 481.…”

High pressure extraction of bioactive diterpenes from the macroalgae Bifurcaria bifurcata: an efficient and environmentally friendly approach

“…5 B. bifurcata has already been studied due to its variety of diterpenes. 2,[6][7][8][9][10][11][12] However, only a single detailed study of its lipophilic fraction was performed by GC-MS analysis, in which other compounds were identied and quantied, namely sterols, fatty acids, long-chain aliphatic alcohols, monoglycerides, among others. 5 Several diterpenes were identied in B. bifurcata Soxhlet extract, namely neophytadiene, phytol, trans-geranylgeraniol, 6,7,9,10,11,12,14,15-tetrahydrophytol, 6-hydroxy-13-oxo-7,7 0 ,10,11-didehydrophytol, eleganolone, and 1-acetyl-10,13dioxo-6,7,11,11 0 ,14,15-tridehydrophytol.…”

“…[2][3][4] The chemical composition of this brown macroalga has gained particular attention, due to the abundance of a variety of acyclic diterpenes. [5][6][7][8][9][10][11][12] Compared to their cyclic counterparts, these linear diterpenes are relatively quite rare in nature, 2 yet quite interesting since a vast range of promising bioactivities have been recognized for them. 2,3,7,8,[13][14][15] Recently, Santos et al 5 demonstrated the antioxidant, anti-inammatory and antibacterial activities of B. bifurcata lipophilic extracts, mainly composed of linear diterpenes.…”

Eleganolone, a Diterpene from the French Marine Alga Bifurcaria bifurcata Inhibits Growth of the Human Pathogens Trypanosoma brucei and Plasmodium falciparum

“…B. bifurcata is characterized by polyphenols (phlorotannins) [15,16], fucosterol [17], but mainly by linear oxygenated diterpenes [18,19,20,21,22,23,24,25,26], eleganolone being the major one [27]. Several studies have proven the cytotoxic activities of B. bifurcata and/or its secondary metabolites.…”