Forskolin promotes astroglial differentiation of human central neurocytoma cells

Kim, Bum Joon; Kim, Sung Soo; Kim, Young Im; Paek, Sun Ha; Lee, Young Don; Suh‐Kim, Haeyoung

doi:10.1038/emm.2004.7

Cited by 20 publications

(14 citation statements)

References 28 publications

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“…Nestin is also found in a variety of tumors: brain tumors, gastrointestinal stromal tumors, pancreatic cancer, malignant melanomas, prostate cancer, and breast cancer [4][5][6][7][8][9]. In brain tumors, nestin is expressed in gliomas, medulloblastomas, primitive neuroectodermal tumors, and central neurocytomas [4,[10][11][12][13]. However, little is known about nestin expression in other brain tumors, for example meningiomas, schwannomas, and CNS lymphomas.…”

Section: Introductionmentioning

confidence: 99%

Nestin expression in brain tumors: its utility for pathological diagnosis and correlation with the prognosis of high-grade gliomas

et al. 2012

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One of the type VI intermediate filament proteins, nestin, is expressed in neuroepithelial stem cells during neural embryogenesis. Nestin is also expressed in a variety of neoplasms. Its expression in brain tumors has not been thoroughly studied. The objectives of this study were to survey nestin expression in different types of brain tumor, and to evaluate nestin as a marker for diagnosis and prognosis. We used tissue microarrays of 257 brain tumors for an immunohistochemical overview of nestin expression: nestin was frequently expressed in gliomas and schwannomas. Most of the gliomas that expressed high levels of nestin were high-grade gliomas (anaplastic astrocytomas, anaplastic oligodendrogliomas, anaplastic oligoastrocytomas, and glioblastomas). We then focused on high-grade gliomas and performed immunohistochemistry again, using whole-mount slides. As a result, we found (1) significantly different nestin expression between glioblastomas and other high-grade gliomas, and (2) worse overall survival for high-grade gliomas with high nestin expression. Our results suggest that: (1) nestin is a useful marker for diagnosis of high-grade gliomas, (2) nestin is helpful in diagnosis of schwannomas, and (3) nestin expression is related to poor prognosis in high-grade gliomas.

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Section: Introductionmentioning

confidence: 99%

Nestin expression in brain tumors: its utility for pathological diagnosis and correlation with the prognosis of high-grade gliomas

et al. 2012

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“…Several factors play a role in the regulation of neurogenesis, and in particular, neurotrophic factors are known to be critical for the survival of new-born cells during their development in vivo and in culture (Palmer et al, 1997). Among the factors that are involved in neural and glial differentiation (Aberg et al, 2000;Lee et al, 2003;Kim et al, 2004), brain-derived neurotrophic factor (BDNF) is interesting, because it has been shown to promote the differentiation and survival of progenitor cells in the adult brain (Zigova et al, 1998), and in cultured cells (Vicario-Abejon et al, 1995;Palmer et al, 1997). In addition, singing behavior has also been reported to increase the expression of BDNF, and this was also found to be correlated with the extent of new Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus neuron survival (Li et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus

Lee

Kim²,

Kim³

et al. 2006

Exp Mol Med

112

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New-born cells continue to proliferate and survive to become mature granule cells in adult rat hippocampus. Although this process, known as neurogenesis, is inhibited by acute stress, it is not clear whether chronic stress affects neurogenesis. To determine whether chronic mild stress (CMS) influences neurogenesis in the adult rat hippocampus, male Sprague-Dawley rats were exposed to CMS and administered bromodeoxyuridine (BrdU) before or after CMS to observe the survival/differentiation or proliferation of new-born cells, respectively. In addition, we measured brain-derived neurotrophic factor (BDNF) mRNA in the granule cell layer (GCL) of the hippocampus, because BDNF is known to play an important role in the survival of new-born cells. CMS significantly decreased the survival of newborn cells in the GCL, but did not influence the proliferation or differentiation of new-born cells. CMS did not affect the proliferation and survival of new-born cells in the hilus. In addition, CMS did not change BDNF mRNA levels in the GCL. These results demonstrate that CMS reduces the survival of new-born cells but not of their proliferation, suggesting that repeated mild stress could influence a part of neurogenesis, but not the whole part of neurogenesis. These results raise the possibility that the survival of new-born cells may be suppressed in the presence of normal BDNF mRNA levels in GCL.

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“…It has been speculated that neurocytoma may be derived from the bipotential subependymal plate progenitor cells differentiating to neuronal and glial cells [1][2][3][4][5][6][7][8]. Here we report a case of extraventricular neurocytoma showing the existence of neural stem cells in the paraventricular tissue adherent to the tumor.…”

Section: Introductionmentioning

confidence: 83%

Immunohistochemical Study Concerning the Origin of Neurocytoma—A Case Report

Yano

Ohe

Shinoda³

et al. 2008

Pathol. Oncol. Res.

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A 26-year-old woman presented with rapid tumor growth in her left frontal lobe during 9 years of observation. Operative findings revealed a massive tumor connected to gelatinous, transparent membranous tissue (MT), which extended from the paraventricular zone and continued into the lateral ventricle. Histological diagnosis was atypical neurocytoma. Immunohistochemical analyses revealed that the tumor was strongly positive for not only neural markers but also a glial marker, while the MT was positive for a neural marker. The Ki-67/MIB-1 labeling index was 9.1% in the tumor body and 0% in the MT. Musashi 1, a marker of neural stem cells, was strongly positive in both the tumor body and the MT. We speculate that the tumor growth was due to a rapid decline of the Musashi 1-positive cells to glial differentiation. These cells may be candidates for the origin of the tumor.

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Forskolin promotes astroglial differentiation of human central neurocytoma cells

Abstract: Abbreviations: bFGF, basic fibroblast growth factor; GFAP, glial fibrillary acidic protein; NSE, neuron specific enolase; SNP, synaptophysin

Cited by 20 publications

References 28 publications

Nestin expression in brain tumors: its utility for pathological diagnosis and correlation with the prognosis of high-grade gliomas

Nestin expression in brain tumors: its utility for pathological diagnosis and correlation with the prognosis of high-grade gliomas

Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus

Immunohistochemical Study Concerning the Origin of Neurocytoma—A Case Report

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