Fostering reproducibility in industry-academia research

Jasny, Barbara R.; Wigginton, Nicholas S.; McNutt, Marcia; Bubela, Tania; Buck, Stuart; Cook-Deegan, Robert; Gardner, Timothy S.; Hanson, Brooks; Hustad, Carolyn M.; Kiermer, Véronique; Lazer, David; Lupia, Arthur; Manrai, Arjun K.; McConnell, Laura L.; Noonan, Kevin; Phimister, E.; Simon, Brenda M.; Strandburg, Katherine J.; Summers, Zarath M.; Watts, Duncan J.

doi:10.1126/science.aan4906

Cited by 41 publications

(29 citation statements)

References 8 publications

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“…Although it is clear that open and transparent research practices pose challenges for corporate and corporate-sponsored research [e.g., Jasny et al, 2017], it may be possible to apply them to some types of research (e.g., safety testing), even if they reasonably cannot be applied to others (e.g., product development). Mars, Inc., maker of M&Ms and Wrigley's gum, recently announced that they would not tie research funding to specific outcomes and support studies that can be published freely, regardless of its results [Prentice, 2018].…”

Section: Discussionmentioning

confidence: 99%

Open and transparent research practices and public perceptions of the trustworthiness of agricultural biotechnology organizations

Landrum¹,

Hilgard²,

Lull³

et al. 2018

JCOM

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Public trust in agricultural biotechnology organizations that produce so-called 'genetically-modified organisms' (GMOs) is affected by misinformed attacks on GM technology and worry that producers' concern for profits overrides concern for the public good. In an experiment, we found that reporting that the industry engages in open and transparent research practices increased the perceived trustworthiness of university and corporate organizations involved with GMOs. Universities were considered more trustworthy than corporations overall, supporting prior findings in other technology domains. The results suggest that commitment to, and communication of, open and transparent research practices should be part of the process of implementing agricultural biotechnologies. AbstractPublic perception of science and technology; Public understanding of science and technology; Risk communication

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Section: Discussionmentioning

confidence: 99%

Open and transparent research practices and public perceptions of the trustworthiness of agricultural biotechnology organizations

Landrum¹,

Hilgard²,

Lull³

et al. 2018

JCOM

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“…To echo arguments already made above, most of the published research is difficult (if not impossible) to repeat. And as noted, there has been a long debate in the scientific literature on the repeatability of data [166,167]. Therefore, part of any efforts at clarity and repeatability should be sorting the reality from the fantasy in what we are reading.…”

Section: Discussionmentioning

confidence: 99%

On the Organization of a Drug Discovery Platform

Nosjean¹,

Ferry²

2018

Drug Discovery - Concepts to Market

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Some of the most exciting parts of work in the pharmaceutical industry are the steps leading up to drug discovery. This process can be oversimplified by describing it as a screening campaign involving the systematic testing of many compounds in a test relevant to a given pathology. This naïve description takes place without taking into consideration the numerous key steps that led up to the screening or the steps that might follow. The present chapter describes this whole process as it was conducted in our company during our early drug discovery activities. First, the purpose of the procedures is described and rationalized. Next follows a series of mostly published examples from our own work illustrating the various steps of the process from cloning to biophysics, including expression systems and membrane-bound protein purifications. We believe that what is described here presents an example of how pharmaceutical industry research can organize its platform(s) when the goal is to find and qualify a new preclinical drug candidate using cutting-edge technologies and a lot of hard work.

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“…The mature form of such a linkage is an effective partnership between researchers and others, oriented to solving a practical problem, with a durable relationship between organizations that goes beyond individuals. Such a partnership should have common, synergistic and mutually beneficial objectives and outcomes (Bastow et al, 2014;Jasny et al, 2017;Shneiderman, 2016;Shneiderman & Hendler, 2017). Effective partnerships between university and nonuniversity actors undergird the examples at the beginning of this paper.…”

Section: Lessons For Encouraging More Solution-oriented Social and Bementioning

confidence: 99%

How to Increase the Relevance and Use of Social and Behavioral Science: Lessons for Policy-makers, Researchers and Others

Western

2019

Justice Evaluation Journal

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For at least 40 years, social and behavioral scientists have argued that their disciplines need to do more to help solve real world practical problems. But doing this has proved difficult. In this paper, I describe three success stories where social and behavioral sciences have contributed important solutions and draw out evidence-based lessons for policy-makers, practitioners, university researchers and others who want to promote social and behavioral science informed actionable solutions to real world problems.

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Fostering reproducibility in industry-academia research

Abstract: Sharing can pose challenges for collaborations

Cited by 41 publications

References 8 publications

Open and transparent research practices and public perceptions of the trustworthiness of agricultural biotechnology organizations

Open and transparent research practices and public perceptions of the trustworthiness of agricultural biotechnology organizations

On the Organization of a Drug Discovery Platform

How to Increase the Relevance and Use of Social and Behavioral Science: Lessons for Policy-makers, Researchers and Others

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