Four butenolides are novel cytotoxic compounds isolated from the marine-derived bacterium,Streptoverticillium luteoverticillatum 11014

Li, De Hai; Zhu, Tian Jiao; Liu, Hong Bing; Fang, Yu Chun; Gu, Qian Qun; Zhu, Wei

doi:10.1007/bf02968245

Cited by 61 publications

(26 citation statements)

References 6 publications

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“…Streptoverticillium luteoverticillatum produces four butenolides [160]. These butenolides show cytotoxicity against the murine lymphoma P388 and human leukemia K562 cell lines.…”

Section: Butenolidesmentioning

confidence: 99%

Bioactive compounds from marine actinomycetes

2008

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Actinomycetes are one of the most effi cient groups of secondary metabolite producers and are very important from an industrial point of view. Among its various genera, Streptomyces, Saccharopolyspora, Amycolatopsis, Micromonospora and Actinoplanes are the major producers of commercially important biomolecules. Several species have been isolated and screened from the soil in the past decades. Consequently the chance of isolating a novel actinomycete strain from a terrestrial habitat, which would produce new biologically active metabolites, has reduced. The most relevant reason for discovering novel secondary metabolites is to circumvent the problem of resistant pathogens, which are no longer susceptible to the currently used drugs. Existence of actinomycetes has been reported in the hitherto untapped marine ecosystem. Marine actinomycetes are effi cient producers of new secondary metabolites that show a range of biological activities including antibacterial, antifungal, anticancer, insecticidal and enzyme inhibition. Bioactive compounds from marine actinomycetes possess distinct chemical structures that may form the basis for synthesis of new drugs that could be used to combat resistant pathogens.

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“…Streptoverticillium luteoverticillatum produces four butenolides [160]. These butenolides show cytotoxicity against the murine lymphoma P388 and human leukemia K562 cell lines.…”

Section: Butenolidesmentioning

confidence: 99%

Bioactive compounds from marine actinomycetes

2008

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“…[1][2][3] Butyrolactones were mainly found as metabolites from fungi and high plants in nature. 4 They appeal to medicinal chemists because of their pronounced pharmacological effects including antibacterial, 5,6 anti-tumor, 7,8 anti-inflammatory, 9,10 anti-virus, 11,12 and the like. In previous studies, some butyrolactones were isolated from the fermentation products of fungus Aspergillus.…”

Section: Introductionmentioning

confidence: 99%

Butyrolactones Derivatives from the Fermentation Products of an Endophytic Fungus Aspergillus versicolor

Ye¹,

Xia²,

Yang³

et al. 2014

Bulletin of the Korean Chemical Society

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Two new butyrolactones, asperphenol A (1) and B (2), together with four known butyrolactones (3-6) were isolated from the fermentation products of an endophytic fungus Aspergillus versicolor. Their structures were elucidated by spectroscopic methods including extensive 1D-and 2D-NMR techniques. Compounds 1-6 were also tested for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compound 2 exhibited high anti-TMV activity with inhibition rate of 46.7%. The other compounds also exhibited potential anti-TMV activities with inhibition rates in the range of 21.8-28.4%.

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“…The ions at m/z 207.07 for 1 and m/z 257.08 for 2 were attributed to the loss of C 3 H 8 O 2 , corresponding to propane-2,2-diol, which results from the scission of the 1,2-O-isopropylidene moiety, from the protonated molecule (m/z 283.12 for 1 and m/z 333.14 for 2). The m/z 257.08 ion was also detected for compound 2 in the MS 3 spectrum of the m/z 275.09 ion and results from the loss of wileyonlinelibrary.com/journal/jms 2,4 A + ion (rel. abund.…”

Section: Protonated Compounds 1 Andmentioning

confidence: 99%

Furanose C—C‐linked γ‐lactones: a combined ESI FTICR MS and semi‐empirical calculations study

Madeira¹,

Xavier²,

Rauter³

et al. 2010

J. Mass Spectrom.

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Sugars that incorporate the unsaturated carbonyl motif have become important synthetic targets not only as a result of their potential biological properties but also as precursors in the synthesis of many bioactive products. Moreover, little is known about the influence of the γ-lactone moiety in the fragmentation pattern of furanose rings. Therefore, two α,β-unsaturated γ-lactones (butenolides) and two β-hydroxy γ-lactones, C-C linked to a furanose ring were studied using electrospray ionization FTICR mass spectrometry. The behaviour of the protonated and sodiated forms of the compounds under study has been compared considering their structural features. Fragmentation mechanisms were established and ion structures were proposed taking into account the MS(2) and MS(3) experiments, accurate mass measurements and semi-empirical calculations. These inexpensive methods proved to be a valuable resource for proposing protonation sites and for the establishment of fragmentation pathways.

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Four butenolides are novel cytotoxic compounds isolated from the marine-derived bacterium,Streptoverticillium luteoverticillatum 11014

Cited by 61 publications

References 6 publications

Bioactive compounds from marine actinomycetes

Bioactive compounds from marine actinomycetes

Butyrolactones Derivatives from the Fermentation Products of an Endophytic Fungus Aspergillus versicolor

Furanose C—C‐linked γ‐lactones: a combined ESI FTICR MS and semi‐empirical calculations study

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