Four different malignancies in one patient: a case report

Demirci, Umut; Coşkun, Uğur; Göçün, Pınar Uyar; Gürlek, Bahar; Saka, Burcu; Öztürk, Bayram; Benekli, Mustafa; Büyükberber, Süleyman

doi:10.1186/1757-1626-3-53

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…Eight cases experienced dead/metastasis or recurrence. [ 3 , 4 , 13 , 16 , 17 , 19 , 20 , 24 ] The outcomes of cases were not reported. [ 6 – 9 , 23 ]…”

Section: Discussionmentioning

confidence: 99%

Triple metachronous primary cancer of uterus, colon, and breast cancer

Li¹,

Yao²,

et al. 2020

Medicine

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Rationale: Triple or more primary malignancies are rare, with only 23 previous cases including breast cancer reported in the English language studies between January 1990 and December 2019. Patient concerns: The patient was a 67-year-old woman with a mass in her right breast. She had a previous history of uterine and colon cancer. Both ultrasonography and mammography revealed a Breast Imaging Reporting and Data System (BI-RADS) category 3 breast lesion, in which proliferative nodules are more likely. Given her previous history of 2 malignancies, her doctors strongly recommended a biopsy. Diagnosis and interventions: The biopsy pathology suggested intraductal breast cancer. Mastectomy and sentinel lymph node biopsy were performed. The postoperative pathological diagnosis was invasive ductal carcinoma, grade II, stage I. The sample was positive for estrogen receptor and progesterone receptor and negative for cerbB-2. No radiotherapy or chemotherapy was administered except for endocrine therapy. A follow-up at 19 months showed no breast recurrence or distant metastases. Outcomes: No recurrence or distant metastasis occurred within the 19-month, 11-year, and 20-year follow-ups for breast, colon, and uterine cancers, respectively. Lessons: To our knowledge, this is the first review of triple or more primary malignancies including breast cancer. These malignancies occur predominantly in older female patients. The most prevalent tumors of triple or more primary malignancies including breast cancer occur in the colon, uterus, and lung. A favorable prognosis is associated with early-stage malignancies.

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“…Eight cases experienced dead/metastasis or recurrence. [ 3 , 4 , 13 , 16 , 17 , 19 , 20 , 24 ] The outcomes of cases were not reported. [ 6 – 9 , 23 ]…”

Section: Discussionmentioning

confidence: 99%

Triple metachronous primary cancer of uterus, colon, and breast cancer

Li¹,

Yao²,

et al. 2020

Medicine

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show abstract

Section: Introductionmentioning

confidence: 99%

“…Multiple Primary Malignancies (MPMs) include the presence of two or more distinctive primary malignancies, apart from metastases, in a single patient (1,2). Because of the increasing number of cancer survivors, improved screening and diagnostic systems, and increased number of the older population, MPMs also have been on the rise (2,3). According to the Surveillance, Epidemiology, and End Results Program (SEER) database, malignancies that are seen at the same time or with an interval of two months are synchronous and those seen at an interval of more than two months are metachronous.…”

Section: Introductionmentioning

confidence: 99%

Coincident of Gastrointestinal Stromal Tumor and Two Other Primary Malignancies: A Case Report

Kermani

Kakaei

Tarvirdizade

2019

Iran Red Crescent Med J

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Introduction:Gastrointestinal Stromal Tumor (GIST) is an uncommon mesenchymal tumor of the gastrointestinal tract. It is rarely presented as Multiple Primary Malignancy Syndrome (MPMS) without an association with the familial syndromes. Case Presentation: A 63-year-old Iranian Azeri man admitted to a government hospital, affiliated to the Tabriz University of Medical Sciences, Tabriz, Iran, in 2012. The illness presented with complicated gastrointestinal problems with the diagnosis of GIST of the stomach, treated with imatinib. They family history and the screening tests of malignancies were negative, but the patient diagnosed with Squamous Cell Carcinoma (SCC) of the lower lip, leading to 28 courses of radiotherapy, followed by the recurrence of gastrointestinal symptoms, the GIST and SCC of the esophagus, that was also detected accidentally. Conclusions: Management of the multiple primary malignancy syndrome needs multidisciplinary teamwork. The study of MPMs, its etiology, and epidemiology can provide us proper ways of management.

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A case of quadruple primary malignancies including breast, tongue, and thyroid cancers and osteosarcoma in a young female without karyotype abnormality

et al. 2011

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The patient was a 41-year-old, premenopausal woman with a chief complaint of well-circumscribed palpable, right breast mass without nipple discharge. Although she noticed the lump 3 months previously, the size of the tumor (1.1 × 0.9 cm(2)) had been stable. The patient's mother suffered from gastric cancer. Her previous history of the triple different malignancies was as follows: (1) left osteosarcoma [amputation of left lower leg at 15 years old (y/o)]. After the operation, she was treated with various kinds of anticancer drugs including a total of 45 g ifosphamide and 342 g methotrexate; (2) tongue cancer (right radical neck resection; 23 y/o); and (3) thyroid cancer (right lobectomy; 40 y/o). There was no evidence of recurrence of these malignancies at the present consultation. At the time of tongue cancer operation, chromosome abnormality was investigated, but the results were normal. Physical examination showed a well-delimited, elastic-firm, mobile tumor in the central outer right breast. Regional lymph nodes were not palpable. Mammography showed a focal asymmetry in the right upper breast on the mediolateral oblique view. Ultrasonography revealed a hypoechoic mass with irregular margins. Distant metastases could not be detected by whole-body computed tomography scan. The histology of the Mammotome(®) (vacuum-assisted core needle biopsy) specimen revealed that this tumor was low-grade ductal carcinoma in situ (DCIS). She underwent breast-conserving surgery with sentinel lymph node biopsy. On permanent histopathological examination, the diagnosis of the tumor was intracystic papilloma with low-grade DCIS. Surgical margin was negative, and sentinel lymph node metastases could not be observed. Estrogen and progesterone receptor (ER/PR) were strongly positive, but human epidermal growth factor receptor-2 (HER-2) overexpression was not tested because the lesion was DCIS. She has received no adjuvant therapy and is currently disease free 3 months after surgery.

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Four different malignancies in one patient: a case report

Cited by 4 publications

References 9 publications

Triple metachronous primary cancer of uterus, colon, and breast cancer

Triple metachronous primary cancer of uterus, colon, and breast cancer

Coincident of Gastrointestinal Stromal Tumor and Two Other Primary Malignancies: A Case Report

A case of quadruple primary malignancies including breast, tongue, and thyroid cancers and osteosarcoma in a young female without karyotype abnormality

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