The goal of this article is to establish estimates involving the Yamabe minimal volume, mixed minimal volume and some topological invariants on compact 4-manifolds.In addition, we provide topological sphere theorems for compact submanifolds of spheres and Euclidean spaces, provided that the full norm of the second fundamental form is suitably bounded. K E Y W O R D S 4-manifold, biorthogonal curvature, minimal volume, sphere theorem M S C ( 2 0 1 0 ) Primary: 53C21, 53C23; Secondary: 53C25This concept plays an important role in geometric topology. It is closely related with other important invariants as, for instance, minimal entropy h(M) and simplicial volume ‖ ‖. Paternain and Petean [37] proved that the minimal volume, on a compact manifold , satisfies the following chain of inequalitieswhere ( ) is a positive constant; for more details, we refer the reader to [23,24] and [37]. It should be emphasized that some authors have studied other minimal volume invariants in a similar context (cf. [30,45] and [46]). Among them, let us highlight the following ones: Gromov minimal volume, which is defined by