Four new eudesmane-type sesquiterpenes from the basal leaves of Salvia plebeia R. Br.

New Eudesmane Sesquiterpenoids from Salvia plebeia R. Br.

“…Eudesmane‐12,8‐lactams were extremely rare in nature, being described so far only few such compound had been obtained from Curcuma phaeocaulis . Meanwhile, only a few eudesmane‐12,8‐olides were reported from the genus of Salvia . This work revealed the existence of eudesmane‐12,8‐lactam from Salvia genus for the first time.…”

“…In the 1 H‐NMR spectrum ( Table ), the most representative signals were three singlet methyls at δ (H) 1.11, 1.98, 2.09, an acetoxy methyl at δ (H) 2.29 ( s ), and an olefinic proton at δ (H) 5.76 ( s ). The 13 C‐NMR indicated 17 carbon resonances which included an α , β ‐unsaturated ketone moiety ( δ (C) 159.0, 126.9, and 191.2), an α , β ‐unsaturated‐ γ ‐lactone moiety ( δ (C) 145.2, 122.6, and 170.4), and one oxygenated sp 2 carbon signal at δ (C) 149.0 . These NMR data indicated that 1 was an eudesmanolide .…”

“…The 13 C-NMR indicated 17 carbon resonances which included an a,b-unsaturated ketone moiety (d(C) 159.0, 126.9, and 191.2), an a,b-unsaturated-c-lactone moiety (d(C) 145.2, 122.6, and 170.4), and one oxygenated sp 2 carbon signal at d(C) 149.0. [12][13] These NMR data indicated that 1 was an eudesmanolide. [14] [15] The proton signal at d(H) 5.30 (s), correlated with d(C) 79.6 in the HMQC experiment, was assigned to be H-C(1) based on the HMBC correlation between d(H) 1.11 (Me(14)) and d(C) 79.6.…”

Phytochemical and biological research of Salvia medicinal resources

“…Eudesmane-type sesquiterpenes of S. plebeian leaf, plebeiolide C and plebeiafuran ( Figure 14.1), inhibit NO production in LPS-induced RAW264.7 cells (Dai et al, 2014).…”

Chemical Composition of <i>Salvia plebeian</i> R.Br. Essential Oil and its Larvicidal Activity against <i>Aedes aegypti</i> L

“…This plant has been used in traditional medicines for the treatment of hepatitis, cough, inflammation, and haemorrhoids [11]. Previous phytochemical studies on S. plebeia reported that it contained flavonoids, diterpenoids, triterpenoids, lignans, and caffeic acid derivatives [12][13][14][15][16][17]. The chemical composition of the essential oil of S. plebeia has been determined in previous studies [18,19].…”