Four New Glycosides from the Rhizoma of Anemarrhena asphodeloides

Abstract

Four new compounds, aneglycoside A–C (1–3) and timosaponin U (4), were isolated from the rhizomes of Anemarrhena asphodeloides. Their structures were determined through extensive spectroscopic analysis, chemical characteristics, and high-resolution mass spectrometry (HRMS). All the isolations were evaluated for cytotoxicity against HepG2, Hela, and SGC7901 human cancer lines. Compounds 1, 2, and 4 showed weak antiproliferative activities on HepG2, Hela, and SGC7901 cells.

New Steroidal Saponins from the Rhizomes of Paris vietnamensis and Their Cytotoxicity

“…The 1 H-NMR spectrum of 3 exhibited one olefinic methine proton at δ H 5.73 (1H, br s, H-7). Four angular methyl signals at δ H 0.84 (3H, s, H-18), 1.25 (3H, s, H-19), 0.90 (3H, d, J = 7.2 Hz, H-21) and 0.86 (3H, d, J = 6.3 Hz, H-27) implied that 3 also possessed a steroidal skeleton [ 10 , 11 ]. Correspondingly, one trisubstituted olefinic group at δ C 126.59 (C-7) and 169.05 (C-8) and four angular methyl signals at δ C 17.81 (C-18), 17.83 (C-19), 9.45 (C-21), 17.64 (C-27) were discovered in the 13 C-NMR.…”

“…By extensive phytochemical and pharmacological studies, steroidal saponins have proven to be the chief active ingredients. Their significant bioactivities, including antitumor, anti-inflammatory, anti-melanogenic, antifungal, antiulcerogenic and hemostatic, have been confirmed in recent years [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. As perennial plants, the domestic production of Rhizoma Paridis is insufficient, thus demand exceeds supply [ 2 ].…”