2000
DOI: 10.1074/jbc.275.2.1169
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Four New Members Expand the Interleukin-1 Superfamily

Abstract: We report here the cloning and characterization of four new members of the interleukin-1 (IL-1) family (FIL1␦, FIL1⑀, FIL1, and FIL1, with FIL1 standing for "Family of IL-1"). The novel genes demonstrate significant sequence similarity to IL-1␣, IL-1␤, IL-1ra, and IL-18, and in addition maintain a conserved exon-intron arrangement that is shared with the previously known members of the family. Protein structure modeling also suggests that the FIL1 genes are related to IL-1␤ and IL-1ra. The novel genes form a c… Show more

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Cited by 305 publications
(240 citation statements)
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“…Although sST2 has significant homology with IL-1R, it did not bind to known members of the IL-1 family (8,9,30). Others have isolated a cDNA that encodes a ST2-binding protein (9).…”
Section: Discussionmentioning
confidence: 99%
“…Although sST2 has significant homology with IL-1R, it did not bind to known members of the IL-1 family (8,9,30). Others have isolated a cDNA that encodes a ST2-binding protein (9).…”
Section: Discussionmentioning
confidence: 99%
“…The original vector contains Myc and His tags downstream of the cloned cDNA, therefore, all the IL-1␣ proteins were expressed as double tagged chimeras with N-terminal FLAG and C-terminal Myc and His tags. Fragments encoding human deletion mutants IL-1NTP-VVATN (internal deletion aa 78 -87), IL-1NTP-EDSSS (terminal deletion aa [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19], and IL-1NTP-ITDDD (terminal deletion aa 96 -111) were amplified and cloned into BamHI and XhoI sites of modified pcDNA4/TO/MycHis (see above) vector.…”
Section: Methodsmentioning
confidence: 99%
“…The constantly growing interleukin-1 (IL-1) 1 family currently consists of eight different protein ligands, and as much as 10 surface or soluble receptors (1,2). The IL-1 system represents an evolutionary conserved signaling mechanism homologous to the Drosophila Toll pathway, being a central mediator of the host innate defense mechanisms (3,4).…”
mentioning
confidence: 99%
“…Up to 11 members of this family have been identified to date [72,73]. Of those, only five have been thoroughly studied: IL-1α, IL-1b, IL-18, IL-1RA and the recently reported IL-33.…”
Section: Il-1 and Its Familymentioning
confidence: 99%