Four new taraxastane-type triterpenoic acids from Cirsium setosum

Abstract

Four new taraxastane-type triterpenoids acids 3β,22α-dihydroxy-20-taraxasten-30-oic acid (1), 3β-hydroxy-22-oxo-20-taraxasten-30-oic acid (2), 3-oxo-22α-hydroxy-20- taraxasten-30-oic acid (3), and 3β,19β-dihydroxy-20-taraxasten-30-oic acid (4) were isolated and characterized from Cirsium setosum (Willd.) MB. Their structures were determined by the combination of 1D and 2D NMR experiments ((1)H-(1)HCOSY, HSQC, HMBC and ROESY) and mass spectrometry. Compound 2 exhibited potent selective cytotoxicity against human ovarian cancer cell line A2780 with an IC50 value of 3.9 μM.

Bioassay-Guided Isolation of Triterpenoids as α-Glucosidase Inhibitors from Cirsium setosum

“…The extracts of C. setosum have been marked in the U.S. as supplements for liver and cardiovascular disease [3], and in China as healthcare beverages for hypoglycemic, hypolipidemic, and anti-inflammatory effects [4,5,6,7]. Phytochemical studies on C. setosum revealed that it contained triterpenes, flavonoids, sterols, polyphenols, and glycosides [1,2,8,9]. These components have been shown to have various bioactivities, including antihemorrhagic, anti-inflammatory, antioxidant, and antimicrobial activities [10,11,12].…”

The complete chloroplast genome of Cirsium setosum and its phylogenetic analysis

“…For instance, C. setosum is widely used to treat many types of diseases, including incomplete uterine contraction and bleeding, infectious hepatitis, digestive tract bleeding, cardiovascular disease, and promote aggregation and adhesion of platelets (Lu et al 2015;Ma et al 2016a). Modern phytochemical studies revealed that triterpenes, flavonoids, sterols, polyphenols, and glycosides are its main medicinal ingredients (Luan et al 2016;Ma et al 2016b;Ma, Wen, et al 2016). However, little is known in its biosynthesis mechanism.…”