Four novel Candida species in the Candida albicans/Lodderomyces elongisporus clade isolated from the gut of flower beetles

Ji, Zhao-Hui; Jia, Jian Hua; Bai, Feng‐Yan

doi:10.1007/s10482-008-9282-7

Cited by 26 publications

(18 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The latter three yeast species were isolated from insects collected in Panama and USA (Nguyen et al2007;Suh et al 2008) (Fig 1A). The tree topology is in agreement with topologies obtained previously based on analysis of LSU rDNA (Ji et al 2009) and combined sequences of LSU rDNA and SSU rRNA (Kurtzman & Suzuki 2010). Statistical support for the major branches was, however, low in both studies.…”

Section: Resultssupporting

confidence: 90%

“…Members of the clade were isolated from various sources, such as marine habitats, food, plants, and soil (Lachance et al 2011;Nitiyon et al 2011;Nakase et al 2009;Limtong et al 2012;Sipicszki 2013), soft drinks (Chang et al 2012), and human and animals (Weems 1991;Wingard 1995;Trofa et al 2008;Cooper 2011;Kim & Sudbery 2011;Lachance et al 2011a). Studies conducted in different geographic regions showed that insects frequently host yeasts belonging to the Lodderomyces clade, including the human pathogens (Nguyen et al 2007;Suh et al 2008;Ji et al 2009, Urbina 2012. The discovery of additional new yeast species in the Lodderomyces clade is important for a better understanding of its taxonomy and the evolution of pathogenecity in yeasts.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

DNA barcoding revealed Nematodospora valgi gen. nov., sp. nov. and Candida cetoniae sp. nov. in the Lodderomyces clade

et al. 2016

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

DNA barcoding revealed Nematodospora valgi gen. nov., sp. nov. and Candida cetoniae sp. nov. in the Lodderomyces clade

et al. 2016

View full text Add to dashboard Cite

“…In a complementary study, four novel anamorphic yeast species were isolated from the gastrointestinal tracts of flower-visiting beetles in China (17). These novel insect-associated Candida species closely cluster with the human fungal pathogen Candida albicans/Lodderomyces elongisporus clade (17). The emergence of human pathogenic Cryptococcus species from an ancestral lineage of mycoparasitic and insect frass-associated fungi might be similar to these previously illustrated examples in the ascomycetes.…”

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Phylogeny and Phenotypic Characterization of PathogenicCryptococcusSpecies and Closely Related Saprobic Taxa in the Tremellales

et al. 2009

View full text Add to dashboard Cite

The basidiomycetous yeasts Cryptococcus neoformans and Cryptococcus gattii are closely related sibling species that cause respiratory and neurological disease in humans and animals. Within these two recognized species, phylogenetic analysis reveals at least six cryptic species defined as molecular types (VNI/II/B, VNIV, VGI, VGII, VGIII, and VGIV) that comprise the pathogenic Cryptococcus species complex. These pathogenic species are clustered in the Filobasidiella clade within the order Tremellales. Previous studies have shown that the Filobasidiella clade also includes several saprobic fungi isolated from insect frass, but information evaluating the relatedness of the saprobes and pathogens within this cluster is limited. Here, the phylogeny encompassing a subset of species in the Tremellales lineage that clusters closely with the pathogenic Cryptococcus species complex was resolved by employing a multilocus sequencing approach for phylogenetic analysis. Six highly conserved genomic loci from 15 related basidiomycete species were sequenced, and the alignments from the concatenated gene sequences were evaluated with different tree-building criteria. Furthermore, these 15 species were subjected to virulence and phenotype assays to evaluate their pathogenic potential. These studies revealed that Cryptococcus amylolentus and Tsuchiyaea wingfieldii, two nonpathogenic sibling species, are the taxa most closely related to the pathogens C. neoformans and C. gattii and together with Filobasidiella depauperata form a Cryptococcus sensu stricto group. Five other saprobic yeast species form the Kwoniella clade, which appears to be a part of a more distantly related sensu lato group. This study establishes a foundation for future comparative genomic approaches that will provide insight into the structure, function, and evolution of the mating type locus, the transitions in modes of sexual reproduction, and the emergence of human pathogenic species from related or ancestral saprobic species.Recent phylogenetic and genomic studies of the fungal kingdom have illustrated that analysis of both distantly and closely related species provides insight into the evolutionary trajectories of fungal species (16,53). The Fungal Tree of Life (AFTOL) project applied a high-resolution multilocus sequencing (MLS) approach to 170 species, elucidating broad and specific evolutionary relationships among species (16). Yet, the entire fungal kingdom encompasses an estimated 1.5 million species (14), many more than can be analyzed by this approach. More than 100 fungi have been subjected to wholegenome analysis, including distantly related but also, in some cases, closely aligned species (53). Taken together, these approaches illustrate that comparisons of closely related species, first by MLS and then by whole-genome studies, can impact our understanding of how closely related pathogenic and saprobic fungi have evolved to occupy specialized niches in nature.

show abstract

“…elongisporus, named after Dr Jacomina Lodder, is a yeast first described in 1952 as Saccharomyces elongasporus (van der Walt, 1966). It has been isolated in nature from Californian citrus concentrates and the alimentary tract of flower-visiting beetles and other insects and was first described as a bloodstream isolate in 2008 (Ji et al, 2009;Lockhart et al, 2008;Nguyen et al, 2007). This organism was found after a small percentage of isolates confirmed by Vitek and API 20C (bioMérieux) as Candida parapsilosis gave unexpected CHROMagar results.…”

Section: Discussionmentioning

confidence: 99%

Lodderomyces elongisporus endocarditis in an intravenous drug user: a new entity in fungal endocarditis

Daveson

Woods

2012

Journal of Medical Microbiology

View full text Add to dashboard Cite

Lodderomyces elongisporus has been recently identified in the literature as an infrequent human bloodstream isolate, commonly mistaken for a non-albicans Candida. A case of Lodderomyces endocarditis in an intravenous drug user is described. To our knowledge, this report highlights the first documented case of Lodderomyces as a cause of endocarditis and summarizes the susceptibility patterns in the reported literature. All isolates reported so far have fluconazole MICs of ¡0.25 mg ml "1 . Case reportA 30-year-old male carpenter presented febrile to a hospital emergency department with associated recurrent swelling of his left forefoot. He had experienced a week of night sweats and rigors and no history of foot trauma. He had sought medical treatment in primary care for his foot symptoms in the preceding weeks prior to the commencement of the night sweats. The presumptive diagnosis had been a soft tissue injury and was treated symptomatically with no improvement.His past medical history included depression and claustrophobia. He was known to have a pre-existing cardiac murmur that had never been investigated. He was an intravenous heroin user, cigarette smoker and social drinker. He injected primarily via his left cubital fossa and occasionally the venous networks on the dorsal surfaces of his hands. He last admitted to intravenous drug use 8 weeks prior to presentation. His medications included oral quetiapine and he had no allergies.Vital signs on admission were as follows: temperature 38.4 u C, pulse rate regular at 102 beats min 21 , blood pressure of 102/ 74 and respiratory rate of 18 respirations min 21 . Examination revealed an ejection systolic murmur and oedema localized to the left ankle region associated with full range of movement. There were no peripheral stigmata of endocarditis, neurological abnormalities or cardiac failure.Three sets of blood cultures in addition to standard bloods were taken from two different sites (BacT/ALERT; bioMérieux). The aerobic bottles of all sets flagged positive after approximately 40 h (range 37.6-43.8 h). Yeast was seen on microscopy. Preliminary identification was that of a non-albicans Candida after growth on Sabouraud Dextrose Agar, a negative germ tube test and subsequent isolation of blue/green colonies on CHROMagar Candida media (BD Diagnostics). The isolate was referred to a reference laboratory for definitive identification. A further two sets of blood cultures taken 2 days later also flagged positive prior to the commencement of antifungal agents. He was empirically commenced on caspofungin whilst awaiting further investigations and results. Blood cultures taken 48 h after therapy was commenced had no growth.A transoesophageal echo was performed and demonstrated a bicuspid aortic valve with mild stenosis and aortic regurgitation. Bulky lesions up to 1 cm were attached to both leaflet margins. An MRI of his brain revealed right frontal and left parietal hyperintense lesions on the T2 weighted images consistent with presumed embolic lesions. A bone scan was con...

show abstract

Four novel Candida species in the Candida albicans/Lodderomyces elongisporus clade isolated from the gut of flower beetles

Cited by 26 publications

References 31 publications

DNA barcoding revealed Nematodospora valgi gen. nov., sp. nov. and Candida cetoniae sp. nov. in the Lodderomyces clade

DNA barcoding revealed Nematodospora valgi gen. nov., sp. nov. and Candida cetoniae sp. nov. in the Lodderomyces clade

Phylogeny and Phenotypic Characterization of PathogenicCryptococcusSpecies and Closely Related Saprobic Taxa in the Tremellales

Lodderomyces elongisporus endocarditis in an intravenous drug user: a new entity in fungal endocarditis

Contact Info

Product

Resources

About