Four novel genes associated with longevity found in Cane corso purebred dogs

Abstract

Background Longevity-related genes have been found in several animal species as well as in humans. The goal of this study was to perform genetic analysis of long-lived Cane corso dogs with the aim to find genes that are associated with longevity. Results SNPs with particular nucleotides were significantly overrepresented in long-lived dogs in four genes, TDRP, MC2R, FBXO25 and FBXL21. In FBXL21, the longevity-associated SNP localises to the exon. In the FBXL21 protein, tryptophan in long-lived dogs replaced arginine present in reference dogs. Conclusions Four SNPs associated with longevity in dogs were identified using GWAS and validated by DNA sequencing. We conclude that genes TDRP, MC2R, FBXO25 and FBXL21 are associated with longevity in Cane corso dogs.

Three new genes associated with longevity in the European Bison

“…We did not divide our samples in the two genetic lines for the analysis since the association of the genes and their variants with longevity is not always specific for certain subpopulation of one species and can be found also in different species. For example, associations of SNPs in MC2R gene found in human ( Pilling et al., 2017 ) and also in a dog ( Korec et al., 2022 ). FOXO3 also plays a role in longevity in multiple species ( Sanese, Forte, Disciglio, Grossi & Simone, 2019 ).…”

“…Previously, we succeeded with similar strategy in finding longevity-related SNPs in the genome of purebred dog Cane corso ( Korec et al., 2022 ). Using this methodology, we have now identified three SNPs that are significantly overrepresented in long-lived individuals of European bison.…”

“…Longevity-associated genes have been described in humans, mice, dogs and in other animals ( Korec, Ungrová, Hejnar & Grieblová, 2022 ; Pilling et al., 2017 ; Shadyab et al., 2015 ; Singh, Demmitt, Nath & Brunet, 2019 ). In cattle, longevity is most of the time described as a productive lifespan, not a whole-life lifespan ( Mészáros, Eaglen, Waldmann & Sölkner, 2014 ; Steri, Moioli, Catillo, Galli & Buttazzoni, 2018 ).…”