Four potential biomarkers as prognostic factors in stage III serous ovarian adenocarcinomas

Partheen, Karolina; Levan, Kristina; Österberg, Lovisa; Claesson, Ingela; Fallenius, Ghita; Sundfeldt, Karin; Horváth, György

doi:10.1002/ijc.23758

Cited by 76 publications

(54 citation statements)

References 48 publications

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“…In the present study, the expression and function of CapG in CRC were investigated, and the results demonstrated that the expression level of CapG protein in CRC tissue was significantly higher than in non-tumor tissue. This observation was consistent with the results of studies regarding other types of cancer, including oral (18), pancreatic (19), ovarian (20)(21)(22) and breast cancer (23). In the present study, the positive expression of CapG in the cytoplasm and nucleus was significantly associated with CRC location, differentiation, LMN status and clinical stage.…”

Section: Discussionsupporting

confidence: 93%

Function of the macrophage‑capping protein in colorectal carcinoma

Chen²,

Ding

et al. 2017

Oncol Lett

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Abstract.To investigate the role of macrophage-capping protein (CapG) in the development and progression of colorectal carcinoma (CRC), immunohistochemistry (IHC), Kaplan-Meier survival analysis, wound healing and Transwell migration assays were performed. The IHC results demonstrated that CapG was relatively highly expressed in CRC tissue compared with non-tumor tissue (P<0.001), and that the expression of CapG was significantly associated with the tumor site, differentiation, lymph node metastasis and clinical stage (P=0.021, P=0.036, P=0.012 and P=0.009, respectively). Wound healing and Transwell migration assays demonstrated that the reduction of CapG expression in a CRC cell line by RNA interference was associated with significantly impaired motility (P<0.001). Kaplan-Meier survival analysis revealed that the expression of CapG in tumor samples was not significantly associated with disease-free survival time. In conclusion, CapG was overexpressed in CRC and was associated with tumor progression; therefore, it may be a useful prognostic biomarker and therapeutic target in CRC.

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Section: Discussionsupporting

confidence: 93%

Function of the macrophage‑capping protein in colorectal carcinoma

Chen²,

Ding

et al. 2017

Oncol Lett

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“…CapG overexpression has been reported in several cancer types, such as breast carcinoma (Kang et al, 2010;Xu et al, 2010), ovarian adenocarcinoma (Partheen et al, 2008), oral carcinoma (Nomura et al, 2008), pancreatic cancer (Thompson et al, 2007a,b), and ocular melanoma (Van Ginkel et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Evaluation of CapG, Gelsolin, P‐gp, GSTP1, and Topo‐II Proteins in Non‐Small Cell Lung Cancer

Zhu

Hunag

Liu

et al. 2011

The Anatomical Record

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Metastasis and multidrug resistance (MDR) are the main reasons for the poor prognosis of non-small cell lung cancer (NSCLC) patients. The use of biomarkers may contribute to a more accurate prediction of tumor metastasis, a better response to chemotherapy, and better patient survival. Gelsolin-like actin-capping protein (CapG) and gelsolin have been identified as playing important roles in tumor invasion and metastasis. Permeability glycoprotein (P-gp), glutathione S-transferase pi (GSTP1), and topoisomerase-II (Topo-II) are proteins that are closely related to MDR. In this study, we assessed the prognostic significance of CapG and gelsolin (both markers of tumor motility), and of P-gp, GSTP1, and Topo-II (markers of MDR) in NSCLC patients. One hundred and twenty-one patients with pathologically confirmed, resectable NSCLC were included in the study. The expression levels of the five kinds of proteins mentioned above were determined by immunohistochemistry (IHC). The correlation between the clinical characteristics and IHC findings were analyzed. Expression of CapG, gelsolin, and P-gp was found to be associated with an increased risk of death (Hazard Ratio (HR) ¼ 2.799, 95% Confidence Interval (CI) ¼ 1.2705-6.169, P ¼ 0.011; HR ¼ 3.968, 95% CI ¼ 1.811-8.693, P ¼ 0.001; HR ¼ 3.251, 95% CI ¼ 1.456-7.260, P ¼ 0.004, respectively), whereas expression of GSTP1 and Topo-II was not. These results suggest that higher tumor motility and MDR may be important in NSCLC prognosis. Anat Rec, 295:208-214, 2012. V V C 2011 Wiley Periodicals, Inc.Key words: NSCLC; CapG; gelsolin; P-gp; prognosisLung cancer remains the leading cause of cancerrelated deaths in China, in both males and females. The most common form of lung cancer, non-small cell lung cancer (NSCLC), has a 5-year relative survival rate below 70% in patients with Stage I tumors, and below 1% in patients with Stage IV tumors (Jemal et al., 2009). Treatment of patients with NSCLC is governed by various prognostic factors such as surgical stage, histological grade, differentiation, and lymph node metastasis. Nevertheless, the clinical outcome in individual patients is often difficult to predict.The main cause of death from lung cancer is usually related to metastasis and resistance to chemotherapeutics after primary surgery. If prognosis could be determined more precisely before treatment, then patients would be more effectively treated with individualized therapy. Compared with mRNAs, which degrade quickly if samples are not prepared correctly, proteins are more stable and potentially very useful biomarkers. Furthermore, differences in protein expression may reveal information about biological properties of tumors.

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“…Significant overexpression of the CapG protein was detected in pancreatic cancer (Thompson et al 2007) and oral squamous-cell carcinoma (Nomura et al 2008), with associations with large tumor size and advanced staging in the case of oral squamous-cell carcinoma. CapG is also expressed at higher levels in ovarian carcinomas with possible correlations with advance disease stage and survival (Partheen et al 2008). Our results showed that lung adenocarcinoma tissues had significantly increased expression of CapG immunoreactivity compared to adjacent tumor-free tissues.…”

Section: Discussionmentioning

confidence: 52%

Overexpression of Gelsolin-Like Actin-Capping Protein Is Associated with Progression of Lung Adenocarcinoma

Shao

Zhang

Don

et al. 2011

Tohoku J. Exp. Med.

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Gelsolin-like actin-capping protein (CapG), a ubiquitous actin-binding protein, has been shown to play a critical role in regulating the migration ability of cells. In this study, we investigated CapG expression in lung cancer cell lines under hypoxia and evaluated the effect of CapG on the migration ability of these cells. We also analyzed the expression of CapG in a total of 75 patients with lung adenocarcinoma by immunohistochemistry. Our results showed that hypoxia increased the expression of CapG in the human lung cancer cell lines, A549 and H358. Knockdown of CapG expression with small interfering RNA led to a decrease in the migration ability of these cell lines. These results indicate that CapG expression is upregulated in lung cancer cell lines under hypoxia and that CapG may contribute to the migration ability of lung cancer cells. Moreover, the excised lung adenocarcinoma tissues showed significantly increased immunoreactivity for CapG, compared to the adjacent tumor-free tissues. Importantly, overexpression of CapG is significantly associated with male sex (χ 2 = 5.195, p = 0.033) and lymph node metastasis (χ 2 = 5.58, p = 0.021). Likewise, CapG overexpression was observed with advanced tumor stages (III and IV, 16/31), compared with early tumor stages (I and II, 14/44), but the difference was not statistically significant. These results suggest that overexpression of CapG may be associated with progression of lung adenocarcinoma. In conclusion, CapG may be a promising target for therapy and a potential biomarker for predicting the prognosis of lung adenocarcinoma.

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Four potential biomarkers as prognostic factors in stage III serous ovarian adenocarcinomas

Cited by 76 publications

References 48 publications

Function of the macrophage‑capping protein in colorectal carcinoma

Function of the macrophage‑capping protein in colorectal carcinoma

Prognostic Evaluation of CapG, Gelsolin, P‐gp, GSTP1, and Topo‐II Proteins in Non‐Small Cell Lung Cancer

Overexpression of Gelsolin-Like Actin-Capping Protein Is Associated with Progression of Lung Adenocarcinoma

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