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AbstractKolya Uraltsev was one of the inventors of the Heavy Quark Expansion (HQE), that describes inclusive weak decays of hadrons containing heavy quarks and in particular lifetimes. Besides giving a pedagogic introduction into the subject, we review the development and the current status of the HQE, which just recently passed several non-trivial experimental tests with an unprecedented precision. In view of many new experimental results for lifetimes of heavy hadrons, we also update several theory predictions:06. The theoretical precision is currently strongly limited by the unknown size of the nonperturbative matrix elements of four-quark operators, which could be determined with lattice simulations. * Alexander. Lenz@durham.ac.uk