Four years retrospective study of skin adnexal tumors: Histomorphology and special stain study

Omar, Amany M.; Osman, Nisreen Abdel Tawab Abdel Gaber

doi:10.5455/ijmsph.2020.02036202011032020

Cited by 3 publications

(19 citation statements)

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“…These variations may be explained by methodological, clinical practice and population‐specific differences. The literature is summarized in Table S4 (see Supporting Information) 3,9,12–33 . Our population had a significantly higher female representation (male to female ratio of 0·77 : 1) than that found in the reported literature (male to female ratio of 0·98 : 1) and had a proportionally low number of malignant cases (2·8%; 45 of 1615) compared with the literature (9·4%; 204 of 2167).…”

Section: Discussionmentioning

confidence: 69%

“…We found the most common benign SAT in adults to be hidrocystoma, followed by pilomatrixoma, trichilemmoma, cylindroma and spiradenoma. In the published literature, the most frequent tumours have been pilomatrixomas (11 of 24 studies), 12,14,17,19,21,[24][25][26][31][32][33] with hidradenomas (six of 24 studies) 13,15,20,24,27,30 also being frequently observed. We also analysed paediatric tumours (in patients aged ≤ 18 years), and found that they accounted for 10% of our caseload.…”

Section: Discussionmentioning

confidence: 99%

“…Limitations of this work include its retrospective design, as seen in similar studies of this nature, 9,30,31,40 and the fact that the clinical data available was limited to only the data that was provided to the pathologists. As such, the true rate of genetically related SATs in this cohort cannot be determined, and are best addressed by future prospective studies where genetic data from each patient with an SAT are captured.…”

Section: Discussionmentioning

confidence: 99%

“…Our 5-year data from a UK tertiary referral centre report on a significantly different population of patients from that found in the recent literature, and add new insights and context to the recent literature from Asia and the Middle East. 9,30,31,40 The diagnosis of SATs is important, and we propose the following: (i) a standardized reporting template when a benign SAT known to be linked to a genetic diagnosis is reported, including a recommendation to consider CPC and/or genetic consultation, and (ii) that skin surgeons and pathologists receive clinical dermatogenetic training as part of their continuing professional development for the management of head and neck skin tumours, so that they are better placed to consider SATs when presented with a tumour on the head and neck and obtain additional clinical information (such as the presence of multiple SATs presenting in an individual) in order to discriminate sporadic from genetically related SATs. It is possible that SATs have been overlooked, as the majority are benign and solitary; however, malignant tumours and genetic syndromes comprise an important proportion of SATs and we suggest that diagnosis and management of these tumours could be improved, which would benefit patients and their families.…”

Section: Discussionmentioning

confidence: 99%

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A 5-year retrospective review of skin adnexal tumours received at a tertiary dermatopathology service: implications for linked genetic diagnoses

Cook

Bajwa

Hollestein

et al. 2022

British Journal of Dermatology

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Background Skin adnexal tumours (SATs) comprise a diverse range of neoplasms, which are difficult to diagnose clinically. They present in paediatric and adult populations, and may be indicative of an underlying genetic syndrome. There is a lack of recent data on the presentation of these tumours in clinical practice in European populations. Objectives To characterize the clinical and pathological features of SATs received at a single tertiary centre over a 5-year period. Methods A retrospective health record audit of SATs received at the Department of Cellular Pathology, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, during the period November 2012 to October 2017 was performed. Results In total, 107 144 skin cases were received during the audit period. A total of 1615 cases of SATs from 1359 patients were included; 1570 (97Á2%) were benign and 45 (2Á8%) were malignant. Overall, the average age at presentation was 55 years (range 11 months to 97 years) and the male to female ratio was 0Á77 : 1. Sweat gland and hair follicle SATs were most frequently excised; in adults, the most frequent tumour was hidrocystoma, and in children, pilomatrixoma occurred most often. Prebiopsy diagnosis was correct in 28% of cases. Benign SATs are often markers of an associated genetic condition, which warrants improved discrimination of sporadic from genetically related SATs. Conclusions SATs are difficult to diagnose clinically, and clinicopathological correlation may help enhance discrimination of genetically related SATs from sporadic cases. These data have implications for clinical and dermatopathological training provision, the development of reporting standards, and genetic assessment of selected patients.What is already known about this topic?• Skin adnexal tumours (SATs) comprise a diverse range of neoplasms, which arise from the hair follicle, sebaceous and eccrine glands.• Clinical diagnosis is difficult owing to the lack of discriminatory features.• Selected SATs are recognized markers of underlying genetic conditions, but the proportion of these tumours occurring in unselected European populations is not known.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A 5-year retrospective review of skin adnexal tumours received at a tertiary dermatopathology service: implications for linked genetic diagnoses

Cook

Bajwa

Hollestein

et al. 2022

British Journal of Dermatology

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“…In our study, skin adnexal lesions (13 cases) and parasitic lesions (6 cases) were found in Group 2 only, though there are reports of parasitic lesions and skin adnexal neoplasms occurring in distal extremities. [22,23]…”

Section: Discussionmentioning

confidence: 99%

Cytological diagnosis of soft-tissue lesions: A study of variation in site of occurrence

Sharma

Prakash

Kalra

et al. 2021

IJMS

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Objectives: Fine-needle aspiration cytology is a useful diagnostic tool for soft-tissue lesions, which helps in further management of patient. Although, various soft-tissue lesions have preference for particular site of human body, yet usefulness/role of site in cytological diagnosis in the published literature is not very well highlighted. In this study, our aim was to analyze the location of soft-tissue lesions as encountered in cytology practice. Material and Methods: Details of soft-tissue lesions who underwent fine-needle aspiration in a period of 12 months were analyzed. Age, gender, and site of soft-tissue lesion were noted. All the soft-tissue cases were divided into two categories. Group 1 – soft-tissue lesions situated at elbow, forearm, wrist, and hand for upper extremities; and knee, lower leg, ankle, and foot for lower extremities. Group 2 – soft-tissue lesions occurring at other sites. Pearson’s Chi-square test and significance of difference between proportions were analyzed to assess the significance. Results: A total of 928 cases were reported over a period of 12 months. Soft-tissue lesions in Group 1 and Group 2 were 172 and 756 cases, respectively. All the soft-tissue lesions except ganglion cyst (GC) and giant cell tumor (GCT) of tendon sheath are more prevalent in Group 2. There was a statistically significant association (P < 0.001) between cytological diagnosis of soft-tissue lesion and site of lesion. The difference in occurrence of epidermal inclusion cyst, GC, and GCT of tendon sheath between Groups 1 and 2 was found to be statistically significant (P < 0.001). Conclusion: We found significant difference in occurrence of some of the soft-tissue lesion at distal extremity as compared to other location. This may be helpful in arriving at a proper cytological diagnosis.

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Five‐year pattern of adnexal tumors of the skin in Ethiopia

Abdullahi,

Hailu,

Kidane

et al. 2024

Int J Dermatology

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BackgroundAdnexal tumors of the skin are rare neoplasms that encompass a wide range of dermatologic entities. Here, we investigated the pattern of adnexal tumors of the skin in the All African Leprosy and Tuberculosis Rehabilitation and Training Center (ALERT) hospital retrospectively.MethodsA hospital‐based retrospective study was conducted at ALERT from histopathology records in the Armauer Hansen Research Institute (AHRI) pathology laboratory of patients diagnosed with any of the skin adnexal tumors during the time period January 2017 to December 2021. A structured data extraction sheet was used. Data entry was done using EpiData 4.6.0.6. Data were analyzed using SPSS version 25.ResultA total of 146 skin adnexal tumors were identified making the magnitude 2.8% of total biopsies. The 3rd decade of life was found to be the most common age group. Male‐to‐female ratio was 1 : 1.05. Majority of the tumors were benign (82.2%) and had sweat gland differentiation at 48.6%. Poroma (10.9%) was the most frequent tumor, whereas porocarcinoma (6.8%) made up the most frequent malignant tumor. The most common site was the head and neck region (48.6%). Only 21.2% of the tumors were correctly identified clinically.ConclusionThe magnitude of skin adnexal tumors is found to be slightly higher than other similar studies which could be because it was carried out in the largest dermatologic center in the country. The most common skin adnexal tumors identified, their localizations, and lines of differentiation are all in line with other studies. Histopathologic examination is mandatory for the accurate diagnosis of these tumors.

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Four years retrospective study of skin adnexal tumors: Histomorphology and special stain study

Cited by 3 publications

References 0 publications

A 5-year retrospective review of skin adnexal tumours received at a tertiary dermatopathology service: implications for linked genetic diagnoses

A 5-year retrospective review of skin adnexal tumours received at a tertiary dermatopathology service: implications for linked genetic diagnoses

Cytological diagnosis of soft-tissue lesions: A study of variation in site of occurrence

Five‐year pattern of adnexal tumors of the skin in Ethiopia

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