Fourier Transform Infrared Spectroscopic Studies of Cross‐Linked Human Serum Albumin Microcapsules. 3. Influence of Terephthaloyl Chloride Concentration on Spectra and Correlation with Microcapsule Morphology and Size

Lévy, M.-C.; Lefebvre, Sandrine; Andry, M.-C.; Manfait, Michel

doi:10.1002/jps.2600840208

Cited by 13 publications

(5 citation statements)

References 9 publications

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“…Nowadays artificial capsules can be produced in large quantities by first creating an emulsion and then adding a cross-linking agent to form a membrane around the droplets (Chang et al 1966;Lévy et al 1991Lévy et al , 1994Lévy et al , 1995Edwards-Lévy et al 1993Andry et al 1996). This results in the fabrication of capsules that are approximately spherical in shape.…”

Section: Introductionmentioning

confidence: 99%

Off-plane motion of a prolate capsule in shear flow

2013

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The objective of this study is to investigate the motion of an ellipsoidal capsule in a simple shear flow when its revolution axis is initially placed off the shear plane. We consider prolate capsules with an aspect ratio of two or three enclosed by a membrane, which is either strain-hardening or strain-softening. We seek the equilibrium motion of the capsule as we increase the capillary number $\mathit{Ca}$, which measures the ratio between the viscous and elastic forces. The three-dimensional fluid–structure interaction problem is solved numerically by coupling a boundary integral method (for the internal and external flows) with a finite element method (for the wall deformation). For any initial inclination with the flow vorticity axis, a given capsule converges towards a unique equilibrium configuration which depends on $\mathit{Ca}$. At low capillary number, the stable equilibrium motion is the rolling regime: the capsule aligns its long axis with the vorticity axis, while the membrane tank-treads. As $\mathit{Ca}$ increases, the capsule takes a complex wobbling motion at equilibrium, precessing around the vorticity axis. As $\mathit{Ca}$ is further increased, the capsule long axis oscillates about the shear plane, while the membrane rotates around a capsule cross-section that also oscillates over time (oscillating–swinging regime). The amplitude of the oscillations about the shear plane decreases as $\mathit{Ca}$ increases and the capsule finally takes a swinging motion in the shear plane. It is found that the transitions from rolling to wobbling and from wobbling to oscillating–swinging depend on the mean energy stored in the membrane.

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Section: Introductionmentioning

confidence: 99%

Off-plane motion of a prolate capsule in shear flow

2013

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“…As the reaction time increases, more functional groups are involved in the reaction producing rough and more granular microcapsules. 6 Similarly, with the increase in the concentration of crosslinker, a rough membrane is formed, showing a higher degree of crosslinking. 4,6…”

Section: Introductionmentioning

confidence: 98%

“…6 Similarly, with the increase in the concentration of crosslinker, a rough membrane is formed, showing a higher degree of crosslinking. 4,6…”

Section: Introductionmentioning

confidence: 98%

Study of the interfacial viscoelasticity of human serum albumin microcapsules using a viscoelasto-electrohydrodynamic technique

Puri¹,

Thaokar²

2023

Soft Matter

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“…At pH 9.8 (carbonate buffer) with 2 min reaction time, bigger ∼ 30 µm capsules with smooth membrane morphology is formed, while as the reaction time increases, smaller microcapsules with rough morphology are obtained. Initially, only free amines participate in the reaction, and as the reaction time increases, more functional groups are involved in the reaction producing rough and more granular microcapsules [30]. Similarly, with the increase in the concentration of crosslinker, a rough membrane is formed, showing a higher degree of crosslinking [30,29].…”

Section: Introductionmentioning

confidence: 99%

“…Initially, only free amines participate in the reaction, and as the reaction time increases, more functional groups are involved in the reaction producing rough and more granular microcapsules [30]. Similarly, with the increase in the concentration of crosslinker, a rough membrane is formed, showing a higher degree of crosslinking [30,29].…”

Section: Introductionmentioning

confidence: 99%

Study of Interfacial Rheology of Human Serum Albumin Microcapsules using Electrodeformation Technique

Puri¹,

Thaokar²

2022

Preprint

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Understanding the mechanical characterization of microcapsules is critical for their precise applications, such as in pharmaceuticals, cosmetics, agriculture, food industries, etc. Microcapsules synthesized from different materials show distinct mechanical characteristics. It is therefore necessary to study these systems considering their respective micro-physics for an exact theoretical model suitable to these systems. In the present work, we conducted mechanical characterization of the membrane of human serum albumin (HSA) microcapsules using the electrodeformation technique. Proteins are widely used as encapsulating materials for many biomedical and food industries. Relating the microstructure to the mechanical properties of a protein-membrane is a challenge owing to its complex structure and sensitivity towards different environmental conditions such as pH, temperature, and solvents. Interfacial rheology of human serum albumin microcapsules studied using the electrodeformation technique shows that HSA capsules are strain-softening in nature. The viscoelasto-electrohydrodynamic model was utilized to understand the creep mechanism in the human serum albumin capsules. The effect of different reaction parameters such as protein concentration and pH on the morphology of the capsule membrane was investigated, and an attempt has been made to correlate microstructure with the mechanical properties. The pH has a remarkable effect on the morphology of HSA microcapsules which is also reflected in their mechanical characteristics. The capsule synthesized with carbonate buffer shows very distinct morphology with pores on the membrane surface, making the membrane less elastic with significant nonrecoverable creep. The capsules synthesized with different protein concentrations at the same pH condition show different morphology and thus different rheological properties. Capsules with a low concentration of HSA show smooth membrane structure with higher Young's modulus than

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Fourier Transform Infrared Spectroscopic Studies of Cross‐Linked Human Serum Albumin Microcapsules. 3. Influence of Terephthaloyl Chloride Concentration on Spectra and Correlation with Microcapsule Morphology and Size

Cited by 13 publications

References 9 publications

Off-plane motion of a prolate capsule in shear flow

Off-plane motion of a prolate capsule in shear flow

Study of the interfacial viscoelasticity of human serum albumin microcapsules using a viscoelasto-electrohydrodynamic technique

Study of Interfacial Rheology of Human Serum Albumin Microcapsules using Electrodeformation Technique

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