Fournier’s Gangrene in a Neonate With Acute Myeloid Leukemia: A Case Report

Mosayebi, Ziba; Omidian, Ali; Movahedian, A H; Kompani, Farzad; Hosseininodeh, Seyyed Saeed

doi:10.5812/ijp.4537

Cited by 11 publications

(22 citation statements)

References 12 publications

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“…Further assessment of eligibility, based on full-text papers, led to the exclusion of nineteen papers. Finally, 35 papers (6 case series and 29 case reports) involving a total of 44 patients were included in the final analysis ( Figure 1 ) [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ].…”

Section: Resultsmentioning

confidence: 99%

Fournier’s Gangrene in Patients with Oncohematological Diseases: A Systematic Review of Published Cases

et al. 2021

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Patients suffering from hematological malignancies are at increased risk of Fournier’s gangrene (FG) due to immunosuppression caused by the disease itself or by disease-related treatments. A systematic review of PubMed, ISI Web of Knowledge, and Scopus databases was performed in June 2021. We included full papers that met the following criteria: original research, human studies, and describing clinical presentation, treatment, and outcomes of FG in patients with oncohematological diseases. We identified 35 papers published from 1983 to 2021 involving 44 patients (34 males, 8 females) aged between 4 days and 83 years. The most common malignant hematological disorders were acute myeloid leukemia (n = 21) and acute lymphocytic leukemia (n = 9). In 10 patients FG represented the first presentation of hematological malignancy. Scrotum (n= 27) and perineum (n = 11) were the sites most commonly involved. Pseudomonas aeruginosa (n = 21) and Escherichia coli (n = 6) were the most commonly isolated microorganisms. Surgery was performed in 39 patients. Vacuum-assisted closure and hyperbaric oxygen therapy were adopted in 4 and in 3 patients, respectively. Recovery was achieved in 30 patients. FG-related mortality was observed in 11 patients. FG should be carefully considered in patients with oncohematological diseases.

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Section: Resultsmentioning

confidence: 99%

Fournier’s Gangrene in Patients with Oncohematological Diseases: A Systematic Review of Published Cases

et al. 2021

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“…[ 2 ] Although commonly described in adult males, FG has been reported in the neonates, early childhood as well as in the females. [ 3 4 5 ]…”

Section: Introductionmentioning

confidence: 99%

Pattern and outcome of management of Fournier's gangrene in a resource-constraint setting

et al. 2020

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Introduction: Fournier's gangrene (FG) is a necrotizing fasciitis of the external genitalia and perineum but may involve upper thigh and anterior abdominal wall. Patients and Methods: This is a retrospective study of 47 patients managed for FG at Usmanu Danfodiyo University Teaching Hospital from January 2001 to June 2017. Data were entered into a semi-structured pro forma and analyzed using SPSS version 20.0. Results: The mean age of the patients was 42.7 ± 19.4 years, with age range of 7 weeks to 72 years. All the patients were male. The patients had underlying urologic conditions in 27.6%, 15.0% were postoperative, 4.2% had anorectal diseases, 10.6% had medical conditions, and 42.6% were idiopathic. After resuscitation, all the patients had serial debridement, Hypertonic saline bath, broad spectrum antibiotics and wound dressing. The wound healed by secondary intention in 34.0% and 32.3% of the patients had wound closure ± skin graft. The treatment was successful in 68.0% of the patients, 15.0% left against medical advice, and 17.0% died of severe sepsis. Conclusion: FG mainly affects men with existing urologic conditions in our environment. Aggressive debridement, hypertonic saline sitz bath, broad-spectrum antibiotics, and appropriate wound care are associated with good outcome.

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“…Yoshino et al [6] described the case of an anal fistula in a patient with type 2 diabetes mellitus, resulting in an abscess of pararectal tissue complicated by Fournier gangrene. Mosayebi et al [7] described Fournier gangrene in a newborn with acute myeloid leukemia. Ishida et al [8] led a clinical case of the occurrence of Fournier gangrene in a patient who received chemotherapy for colon cancer.…”

Section: Epidemiological Situationmentioning

confidence: 99%

Fournier’s Gangrene: Literature Review and Clinical Cases

Chernyadyev¹,

et al. 2018

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Background: Fornier gangrene is an extremely rare disease of the genitals. This disease is a result of the urogenital tract, anorectal area, and genital skin infections, appearing usually in immunocompromised patients with diabetes, obesity, and malignant neoplasms. The basic treatment of Fournier gangrene includes an emergency surgical intervention combined with antibiotic therapy and detoxification. Methods: A review of recent papers comprising studies and reviews published in 2005–2016 was performed. The clinical cases were studied at the Department of Purulent Surgery Central Clinical Hospital No. 1, where 7 patients were diagnosed and treated. Results: The etiology, pathogenesis, clinical and laboratory presentation, diagnosis, treatment, and prognosis of Fournier gangrene are described in this article. The authors have described several clinical cases of patients with Fournier gangrene and with necrotic cellulitis and fasciomyositis of anterior abdominal wall, which is a manifestation of Fournier gangrene. Making allowance for the unfavorable epidemiological situation of syphilis in Russia, the increase in the incidence of complicated, atypical chancre, and therefore, the need for differentiation of Fournier gangrene with such manifestations of syphilis as necrotizing, esthiomenous chancre, indurative edema, the appropriate clinical examples are well explained in this article.

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Fournier’s Gangrene in a Neonate With Acute Myeloid Leukemia: A Case Report

Cited by 11 publications

References 12 publications

Fournier’s Gangrene in Patients with Oncohematological Diseases: A Systematic Review of Published Cases

Fournier’s Gangrene in Patients with Oncohematological Diseases: A Systematic Review of Published Cases

Pattern and outcome of management of Fournier's gangrene in a resource-constraint setting

Fournier’s Gangrene: Literature Review and Clinical Cases

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