Fourth Level: The Limbic System

Cardinali, Daniel P.

doi:10.1007/978-3-319-57571-1_6

Cited by 5 publications

(5 citation statements)

References 52 publications

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“…We clustered 35 selected subcortical structures into five modules. The structures in module I are parts of the limbic system, which is closely related to emotion, memory, and cognition [26], and located in the medial temporal lobe of the cerebrum. The pathological features of the AD first appear in the medial temporal lobe, especially in the hippocampus [27].…”

Section: Discussionmentioning

confidence: 99%

Quantitative Trait Module-Based Genetic Analysis of Alzheimer’s Disease

Yuan

Xie

et al. 2019

IJMS

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The pathological features of Alzheimer’s Disease (AD) first appear in the medial temporal lobe and then in other brain structures with the development of the disease. In this work, we investigated the association between genetic loci and subcortical structure volumes of AD on 393 samples in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. Brain subcortical structures were clustered into modules using Pearson’s correlation coefficient of volumes across all samples. Module volumes were used as quantitative traits to identify not only the main effect loci but also the interactive effect loci for each module. Thirty-five subcortical structures were clustered into five modules, each corresponding to a particular brain structure/area, including the limbic system (module I), the corpus callosum (module II), thalamus–cerebellum–brainstem–pallidum (module III), the basal ganglia neostriatum (module IV), and the ventricular system (module V). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment results indicate that the gene annotations of the five modules were distinct, with few overlaps between different modules. We identified several main effect loci and interactive effect loci for each module. All these loci are related to the function of module structures and basic biological processes such as material transport and signal transduction.

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Section: Discussionmentioning

confidence: 99%

Quantitative Trait Module-Based Genetic Analysis of Alzheimer’s Disease

Yuan

Xie

et al. 2019

IJMS

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“…The limbic system, a set of brain structures connected to the prefrontal cortex, also shapes individuals' motivation behaviors ( 14 ). For example, there is evidence that the mesolimbic structures of the brain, and the mesocorticolimbic circuitry or “reward pathway” of the brain, are responsible for the hedonic aspects of eating and incentive salience in food motivation behaviors ( 15 ).…”

Section: What Is Known In the Literaturementioning

confidence: 99%

Understanding the Neuroscience Underpinnings of Obesity and Depression: Implications for Policy Development and Public Health Practice

Robles

Kuo

Galván

2021

Front. Public Health

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“…Emotions, memory, and behavior mostly emerge from the limbic system, a group of interconnected structures in the brain. Damages or changes in the limbic system can result in dysfunction in various behavioral and cognitive areas (Cardinali, 2018). Electrophysiological studies have shown that the hippocampus is involved with the learning process, and lesions in this area have previously caused learning and memory deficits in animal test subjects (Donkelaar et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Effects of Occupational Formaldehyde Exposure on Passive Avoidance Conditioning and Anxiety Levels in Wistar rats

Resae

Yousefi²,

Naeimi³

et al. 2023

Iran J Vet Med

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Background: Formaldehyde is a volatile organic compound widely used in industry and medical fields such as Anatomy and Pathology. Exposure to this chemical negatively affects the skin, mucous membrane, and respiratory system. It can pass through the blood-brain barrier, potentially causing neurotoxicity. According to studies, formaldehyde might be involved in memory impairment and the cognitive decline process in Alzheimer disease (AD). Objectives: This study aimed to simulate chronic occupational formaldehyde exposure in rats and study its impacts on passive avoidance conditioning and anxiety. Methods: Twenty-four adult male Wistar rats were divided into four groups of 6 rats each. After an adaptation period, the rats were exposed to 1, 2, and 3 ppm formaldehyde vapor in an exposure chamber, 6 hours per day for 7 days. The control group was exposed to saline. After the exposure period, a shuttle box for passive avoidance conditioning and an elevated plus-maze test for assessing anxiety levels were performed. The data were analyzed by 1-way ANOVA and Duncan’s multiple range test for group comparison in SPSS and SAS software. Results: In the shuttle box test, formaldehyde dose-dependently decreased escape-through latency and increased the percentage of dark compartment entries (P<0.0001). In the elevated plus maze test, the percentage of time spent in open arms decreased by increasing the dosage (P<0.0001). Conclusion: Based on these findings, formaldehyde exposure can negatively alter brain function and cause memory impairment and anxiety.

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Fourth Level: The Limbic System

Cited by 5 publications

References 52 publications

Quantitative Trait Module-Based Genetic Analysis of Alzheimer’s Disease

Quantitative Trait Module-Based Genetic Analysis of Alzheimer’s Disease

Understanding the Neuroscience Underpinnings of Obesity and Depression: Implications for Policy Development and Public Health Practice

Effects of Occupational Formaldehyde Exposure on Passive Avoidance Conditioning and Anxiety Levels in Wistar rats

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