2015
DOI: 10.1016/j.gep.2015.04.003
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FOXO1, FOXO3, AND FOXO4 are differently expressed during mouse oocyte maturation and preimplantation embryo development

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Cited by 36 publications
(25 citation statements)
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“…Findings from this study revealed that mRNA levels of several genes having important roles in folliculogenesis and cumulus expansion are similarly expressed in either cumulus or granulosa cells from low and high AF Nelore cows, for example, BMPR2 and TGFß1b (Buratini & Caixeta, ; Caixeta, Sutton‐McDowall et al., ; Weller et al., ), cumulus expansion and oocyte maturation, for example, FSHr (Assidi et al., ; Caixeta, Ripamonte, Franco, Buratini, & Dode, ), cell proliferation, DNA repair and apoptosis, for example, FOXO3a (Kuscu & Celik‐Ozenci, ; Liu et al., ), and oocyte maturation and embryonic development, for example, LIFRα (Mo et al., ). This finding indicates that only certain specific genes involved in the molecular regulation of ovarian functions may be affected by the number of AF present in the ovaries.…”
Section: Discussionmentioning
confidence: 81%
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“…Findings from this study revealed that mRNA levels of several genes having important roles in folliculogenesis and cumulus expansion are similarly expressed in either cumulus or granulosa cells from low and high AF Nelore cows, for example, BMPR2 and TGFß1b (Buratini & Caixeta, ; Caixeta, Sutton‐McDowall et al., ; Weller et al., ), cumulus expansion and oocyte maturation, for example, FSHr (Assidi et al., ; Caixeta, Ripamonte, Franco, Buratini, & Dode, ), cell proliferation, DNA repair and apoptosis, for example, FOXO3a (Kuscu & Celik‐Ozenci, ; Liu et al., ), and oocyte maturation and embryonic development, for example, LIFRα (Mo et al., ). This finding indicates that only certain specific genes involved in the molecular regulation of ovarian functions may be affected by the number of AF present in the ovaries.…”
Section: Discussionmentioning
confidence: 81%
“…TGFß1b (Buratini & Caixeta, 2012;Caixeta, Sutton-McDowall et al, 2013;Weller et al, 2016), cumulus expansion and oocyte maturation, for example, FSHr (Assidi et al, 2008;Caixeta, Ripamonte, Franco, Buratini, & Dode, 2009), cell proliferation, DNA repair and apoptosis, for example, FOXO3a (Kuscu & Celik-Ozenci, 2015;Liu et al, 2007), and oocyte maturation and embryonic development, for example, LIFRα (Mo et al, 2014). This finding indicates that only certain specific genes involved in the molecular regulation of ovarian functions may be affected by the number of AF present in the ovaries.…”
Section: Discussionmentioning
confidence: 99%
“…This response is related to repair, protection, and adaptation, and ultimately to cell survival [51]. FoxO pathway is also activated under stress conditions [50,70]; FoxO molecules have been described in the inner cell mass of mouse blastocysts [71], and the upregulate target genes, thereby promoting cell cycle arrest genes in order to keep cells away from stress. If the cell cycle arrest is not su cient to recover cells, apoptosis is activated, thus producing cell death [71].…”
Section: Discussionmentioning
confidence: 99%
“…FoxO pathway is also activated under stress conditions [50,70]; FoxO molecules have been described in the inner cell mass of mouse blastocysts [71], and the upregulate target genes, thereby promoting cell cycle arrest genes in order to keep cells away from stress. If the cell cycle arrest is not su cient to recover cells, apoptosis is activated, thus producing cell death [71]. In addition, the cellular senescence and cell cycle pathways, which play essential roles in the cell response and cell repair under stressful conditions [71], were also enriched in the vitri ed blastocysts.…”
Section: Discussionmentioning
confidence: 99%
“…Foxo transcription factors regulate many cellular processes, such as apoptosis, cell cycle and differentiation. Foxo promotes growth and development of embryos by regulating the PI3K/AKT signalling pathway . It has been reported that spatiotemporal expression of Foxo4 , which is transcriptionally regulated by PI3K signalling, is involved in the developing brain and retina in zebrafish .…”
Section: Discussionmentioning
confidence: 99%